The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.
They have devised a vaccine that floods the body with an antibody to assault nicotine entering the body.
A study in mice, published in Science Translational Medicine, showed levels of the chemical in the brain were reduced by 85% after vaccination.
Years of research are still needed before it could be tested on people.
However, lead researcher Prof Ronald Crystal is convinced there will be benefits.
"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect."
New approach
Other "smoking vaccines" have been developed that train the immune system to produce antibodies that bind to nicotine - it is the same method used to vaccinate against diseases. The challenge has been to produce enough antibodies to stop the drug entering the brain and delivering its pleasurable hit.
Scientists at Weill Cornell Medical College have used a completely different approach, a gene-therapy vaccine, which they say is more promising.
Continue reading the main story
“Start Quote
If they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit”
Prof Ronald CrystalWeill Cornell Medical College
A genetically modified virus containing the instructions for making nicotine antibodies is used to infect the liver. This turns the organ into a factory producing the antibodies.
The research team compared the amount of nicotine in the brains of normal mice with those that had been immunised. After being injected with nicotine, the vaccinated mice had nicotine levels 85% lower.
It is not known if this could be repeated in humans or if this level of reduction would be enough to help people quit.
Prof Crystal said that if such a vaccine could be developed then people "will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit".
He added: "We are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches."
'Impressive and intriguing'
There are also issues around the safety of gene therapy in humans that will need to be answered.
Professor of genetics at the University of Kent, Darren Griffin, said the findings were "impressive and intriguing with great potential" but cautioned there were still many issues which needed addressing.
He said the main issue "is whether the observed biochemical effects in lab mice genuinely translate to a reduced addiction in humans given that such addictions can be both physical and psychological".
Dr Simon Waddington, from University College London, said: "The technology underpinning gene therapy is improving all the time and it is encouraging to see these preliminary results that indicate it could be used to address nicotine addiction, which is damaging to the nation's health and a drain on the health service economy."
If such a vaccine was developed it could also raise ethical questions about vaccinating people, possibly in childhood, before they even started smoking.
Coca-Cola and Pepsi contain minute traces of alcohol, scientific research published in France has revealed. The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons. According to tests carried out by the Paris-based National Institute of Consumption (INC) more than half of leading colas contain the traces of alcohol. Can't beat the real thing: The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons These include the brand leaders Coca-Cola and Pepsi Cola, while it is mainly only cheap supermarket versions of the drink which are alcohol-free. ‘60 Million Consumers’, the French magazine, publishes the results of the tests in its latest issue. They suggest that the alcohol levels are as low as 10mg in every litre, and this works out at around 0.001 per cent alcohol.
After the recent stream of disturbing news reports of people eating others' flesh, Hornaday Manufacturing has released bullets that promise to ‘make dead permanent.’
The ammunition, branded as Zombie Max offers Proven Z-Max bullets, is live ammunition, but is actually only intended for use on targets – not people.
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The Walking Dead: Hornady Manufacturing has started selling Zombie bullets, 'just in case'; it is live ammunition
Attacks: Carl Jacquneaux, left, who was arrested for allegedly biting another man's face and Brandon De Leon, right, who allegedly tried to bite two policemen while threatening to eat them
Hornaday spokesman Everett Deger told WWJ Newsradio 950 that the company’s president has a love of zombie culture – including popular shows like the Walking Dead – and was inspired to make the bullets in honour of the cultural phenomenon.
ON CLOUD NINE: BATH SALTS BY ANOTHER NAME... WITH STRONG COMPULSIONS TO REDOSE
The 'bath salts' sold under the name Cloud Nine are likely to be stimulant drugs such MPDV or ephedrine.
'Bath salts' does not refer to a single chemical, but instead to a range of synthetic drugs that can be sold legally in the U.S. as long as they are not marked for human consumption – hence the misleading name.
Drugs such as MPDV are highly potent stimulants, similar to some amphetamines, and in MPDV's case particularly, cause a strong compulsion to 'redose' with more of the drug.
In high doses, such drugs can cause violent and unpredictable behaviour, and terrifying hallucinations – and the compulsion to take more of the drug continues, even once the 'high' has begun to make the user feel bad.
Various different compounds use the name 'Cloud Nine', and it's still not confirmed which exact chemical was in the drug reported to have caused these attacks, but some reports have pointed the finger at MPDV.
The chemical is already illegal in Florida – although other 'bath salts' remain perfectly legal in the state.
‘We decided just to have some fun with a marketing plan that would allow us to create some ammunition designed for that…fictional world,’ he told the radio station.
Mr Deger noted that the bullets are some of the ammunition company’s most popular products.
The news comes as two more cannibal attacks have been reported in the US as police warn of a dangerous new mind-altering drug called Cloud Nine.
Last week Rudy Eugene - who is believed to have taken the over-the-counter ecstasy-like drug - growled at officers as he chewed off most of a homeless man's face before being shot dead by Miami police.
Since then two further incidents have been linked to the substance, which is part of a new line of 'bath salts'.
More...
Revealed: Miami cannibal's girlfriend shows herself in public for the first time and claims her beau was carrying a BIBLE before the attack
Caught on camera: The moment woman driver rams into pedestrian and travels for hundreds of yards with him clinging on 'because of her hormones'
Revealed: The videos 'Canadian cannibal' sent to his 'fans' while on the run from police - and one of them contains infamous song from American Psycho
The second occurred on Saturday when a snarling homeless man, identified as Brandon De Leon, threatened to eat two officers, echoing the Miami attack.
A third incident took place in Louisiana where Carl Jacquneaux, 43, bit off a chunk of his victim's face. Miami police have issued a warning about Cloud Nine and told their officers to exercise extreme caution when dealing with homeless men who appear to be acting unusually.
Police investigating the case of Rudy Eugene, who ate the face off a homeless man, say as well as being naked, he was carrying a bible.
Some pages had been ripped out of the book and were found close by, according to CBS Miami. A preliminary toxicology examination has also found that the 31-year-old had been smoked cannabis shortly before the incident.
They were forced to fit 21-year-old De Leon with a Hannibal Lecter-style mask after he was arrested for disturbing the peace in North Miami Beach. When put in a police cruiser De Leon slammed his head against the plexiglass divider and shouted at officers, 'I'm going to eat you', NBC Miami reported.
He then growled, gnashed his teeth and tried to bite the hand of an officer attempting to treat his head wounds.
'Brandon growled and opened and closed his jaw, slamming his teeth like an animal would,' the report said. Miami police said they believe he was on a cocktail of drugs, including Cloud Nine.
In a second case Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.
Victim: Todd Credeur, though in shock, managed to spray his attacker in the face with wasp spray to stop him from eating any more of his face
Scene: Todd Creneur was attacked while working on the yard outside his home in Scott, Louisiana
KATC reported that Mr Credeur was working in his front yard when he was attacked.
Scott Assistant Police Chief Kert Thomas said: 'During the attack, the suspect bit a chunk of the victim's face off.'
Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.
Jacquneaux then allegedly left the home and went to another man's home where he held him at knife point and stole a hand gun. This is where police found him and arrested him.
A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.
Eugene ate the face of homeless man Ronald Poppo in Miami last week and a police memo to officers has highlighted the dangers surrounding the drug's use.
It warned the De Leon case 'bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man's face'.
'Please be careful when dealing with the homeless population during your patrols.'
Police have suggested Eugene was under the influence of the synthetic stimulant usually sold in drug paraphanelia shops.
Cloud Nine is 'addictive and dangerous', the memo said, part of a 'disturbing trend in which new drugs are sold in the guise of household products'.
The drug, which is also as Ivory Wave in the U.S., comes in harmless-looking packets, police said, adding that it is illegal in Britain and Australia.
Crazed attack: Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene (left) when he savagely attacked 65-year-old Ronald Poppo (right)
The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour.
The series of shocking incidents began on May 26 when a naked Eugene encountered his victim, 65-year-old Ronald Poppo, who was sleeping in the shade on elevated train tracks.
In surveillance footage from the nearby Miami Herald building, Eugene was seen struggling with the naked homeless man, throwing him to the ground and then tearing into his face with his teeth as cars and bicycles sped by.
About 18 minutes into the attack, an officer appeared on the scene and yelled at Eugene to stop, but the 31-year-old just growled at him and continued chewing Poppo’s face.
The officer then opened fire on Eugene, shooting him to death.
Enlarge
Horrific attack: The spot on MacArthur Causeway when a man was killed after chewing the face off a stranger
Disfigured: Poppo, here on a stretcher, miraculously survived the attack, but was left without a nose, mouth or eyes
Poppo remains in critical condition at Jackson Memorial Hospital with his nose, mouth and eyes torn off. He faces months of treatment to rebuild his features and psychological care.
Controversially this week the scene of the attack on Poppo has been Miami added to sites visited by a tourist tour's itinerary.
The famous Miami Mystery & Mayhem: Crime Tour tour led by Miami-Dade College professor Dr Paul George will stop on the road that connects downtown Miami to popular South Beach.
Dr Paul told the South Florida Business Journal: 'Horrible as it was, it is part of our history. Currently, our tour takes us over the causeway right past the site, so this fits well.'
In a completely separate case not involving the drug, Canadian Luka Rocco Magnotta has been sent back to his country from Germany after an international manhunt.
He is alleged to have killed his partner, Jun Lin, before eating parts of his body then chopping it to pieces that were then posted to different authorities. Mr Lun's head has not yet been found.
'ZOMBIE APOCALYPSE': RECENT CANNIBAL ATTACKS ACROSS AMERICA
Since Rudy Eugene attacked and ate the face of homeless man Ronald Poppo on May 26 in Miami, Florida, while allegedly high on 'bath salts' there has been a spate of similar attacks.
The 'Miami Cannibal' case shocked the nation after police had to shoot dead Eugene when he refused to stop eating his victim's face off. Poppo is now recovering in hospital with horrific injuries.
Brandon DeLeon, 21, was high on drugs and drunk on Four Loko on June 2 when he tried to bite off a police officer’s hand after he was arrested for disturbing customers in a Miami fast food restaurant.
The homeless man repeatedly banged his head against the patrol car’s Plexiglas and yelled, ‘I’m going to eat you.’
At the police station, De Leon tried to bite the officer who was taking his blood pressure and tending to his self-inflicted wounds. The police report noted that he 'growled and opened and closed his jaw slamming his teeth like an animal would.'
Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.
Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.
A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.
Alex Kinyua, 21, a college student, used a knife to carve up Kujoe Bonsafo Agyei-Kodie, 37, before eating his heart out and parts of his brain.
He then took to his social networking site to boast about it to his friends saying: 'Are you strong enough to endure ritual HBCU mass human sacrifices around the country and still be able to function as human beings?'
He referred to the tragic shootings at Virginia Tech and 'other past university killings around the country' and warned 'ethnic cleansing is the policy, strategy and tactics that will affect you, directly or indirectly in the coming months.'
Narcotic Cloud Nine was blamed for the attack when Rudy Eugene ate 75% of homeless man Ronald Poppo’s face in Miami last month.
Horrific images surfaced of the attack that only ended once police shot and killed 31-year-old Eugene.
Mr Poppo is still recovering from his injuries in hospital.
Police are now warning people to stay away from Cloud Nine – also known as ‘bath salts’ - after two similar attacks were reported.
The most recent prompted an internal memo to police warning officers the case “bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man’s face”.
The memo called the synthetic drug “addictive and dangerous” and said it was part of a “disturbing trend in which new drugs are sold in the guise of household products”.
It added: “Please be careful when dealing with the homeless population during your patrols.”
Rudy Eugene, 31: Ate 75% of a man's face in Miami before being shot dead
AP
Brandon De Leon, 21: Tried to bite two police officers after he was arrested in North Miami BeachCarl Jacquneaux, 43: Bit a man's face in Scott, Louisiania. Wasp spray was used to end the attackAlex Kinyua, 21: Accused of eating the heart and brain of friend in Maryland
Splash
Horror: Film cannibal Hannibal Lecter
Channel 5
During the latest attack homeless Brendon De Leon threatened to eat two Miami police officers and had to be fitted with a Hannibal Lecter-style mask to prevent him carrying his threats out.
He had been arrested for disturbing the peace in North Miami Beach while high on drugs and put in a police cruiser when he slammed his head against the plexiglass divider and shouted: “I’m going to eat you” to officers before growling and baring his teeth.
Miami police said they believe he was on a cocktail of drugs including Cloud Nine.
In another case, Carl Jacquneaux, 43, was accused of attacking Todd Credeur in his front garden in Scott, Louisiana, over the weekend after being upset over a domestic issue while under the influence of what is said to be bath salts.
Jacquneaux bit Mr Credeur before being sprayed in the face with wasp spray.
Scott Assistant Police Chief Kert Thomas said: “During the attack, the suspect bit a chunk of the victim’s face off.”
Jacquneaux was then said to have left the property and gone to another man’s home where he held him at knife-point and stole a handgun before being apprehended by police.
The drug, which is also known as Ivory Wave, was blamed for several deaths in Britain during 2010 before being banned. It is also illegal in Australia.
The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour and is often sold in plain packaging with the contents purporting to be harmless.
Scotland Yard has urged Portuguese authorities to reopen the search for Madeleine McCann as detectives said there are 195 potential leads to finding her alive. The detective leading the Metropolitan Police review said the case can still be solved before officers released a picture of what she might now look like as a nine-year-old. Detective Chief Inspector Andy Redwood said he believes her disappearance was a stranger abduction, as he said there are 195 "investigative opportunities". Police refused to say what evidence they had uncovered to suggest Madeleine is alive. Mr Redwood confirmed that his team of more than 30 officers involved in the case had been out to Portugal seven times, including a visit to the family's holiday flat in Praia da Luz. It will be five years ago next week since the three-year-old went missing as her parents, Kate and Gerry McCann, dined with friends nearby. A spokesman for the McCanns said the family was pleased with the image. Mr Redwood said his 37 officers had dealt with 40,000 pieces of information but the "primacy still sits in Portugal" in the attempt to find her. Commander Simon Foy said: "Most significantly, the message we want to bring to you is that, on the evidence, there is a possibility that she is alive and we desperately need your help today to appeal directly to the public for information to support our investigation." Mr Redwood said "evidence that she is alive stems from the forensic view of the timeline" that there was the opportunity for her to be taken. Investigations show "there do appear to be gaps", he added. Detectives in Portugal are also understood to want the case reopened but must gain judicial approval via the courts.
Companies that do not do enough to keep their websites secure are to be named and shamed to help improve security. The list of good and bad sites will be published regularly by the non-profit Trustworthy Internet Movement (TIM). A survey carried out to launch the group found that more than 52% of sites tested were using versions of security protocols known to be compromised. The group will test websites to see how well they have implemented basic security software. Security fundamentals The group has been set up by security experts and entrepreneurs frustrated by the slow pace of improvements in online safety. "We want to stimulate some initiatives and get something done," said TIM's founder Philippe Courtot, serial entrepreneur and chief executive of security firm Qualys. He has bankrolled the group with his own money. TIM has initially focused on a widely used technology known as the Secure Sockets Layer (SSL). Experts recruited to help with the initiative include SSL's inventor Dr Taher Elgamal; "white hat" hacker Moxie Marlinspike who has written extensively about attacking the protocol; and Michael Barrett, chief security officer at Paypal. Continue reading the main story “ Start Quote Everyone is now going to be able to see who has a good grade and who has a bad grade” Philippe Courtot Many websites use SSL to encrypt communications between them and their users. It is used to protect credit card numbers and other valuable data as it travels across the web. "SSL is one of the fundamental parts of the internet," said Mr Courtot. "It's what makes it trustworthy and right now it's not as secure as you think." Compromised certificates TIM plans a two-pronged attack on SSL. The first part would be to run automated tools against websites to test how well they had implemented SSL, said Mr Courtot. "We'll be making it public," he added. "Everyone is now going to be able to see who has a good grade and who has a bad grade." Early tests suggest that about 52% of sites checked ran a version of SSL known to be compromised. Companies who have done a bad job will be encouraged to improve and upgrade their implementations so it gets safer to use those sites. The second part of the initiative concerns the running of the bodies, known as certificate authorities, which guarantee that a website is what it claims to be. TIM said it would work with governments, industry bodies and companies to check that CAs are well run and had not been compromised. "It's a much more complex problem," said Mr Courtot. In 2011, two certificate authorities, DigiNotar and GlobalSign were found to have been compromised. In some cases this meant attackers eavesdropped on what should have been a secure communications channel. Steve Durbin, global vice president of the Information Security Forum which represents security specialists working in large corporations, said many of its members took responsibility for making sure sites were secure. "You cannot just say 'buyer beware'," he said. "That's not good enough anymore. They have a real a duty of care." He said corporations were also increasingly conscious of their reputation for providing safe and secure services to customers. Data breaches, hack attacks and poor security were all likely to hit share prices and could mean they lose customers, he noted.
Commonly prescribed anti-depressants appear to be doing patients more harm than good, say researchers who have published a paper examining the impact of the medications on the entire body. See Also: Health & Medicine Pharmacology Birth Defects Mental Health Research Mind & Brain Depression Disorders and Syndromes Psychiatry Reference COX-2 inhibitor Psychoactive drug Seasonal affective disorder Anti-obesity drug "We need to be much more cautious about the widespread use of these drugs," says Paul Andrews, an evolutionary biologist at McMaster University and lead author of the article, published recently in the online journal Frontiers in Psychology. "It's important because millions of people are prescribed anti-depressants each year, and the conventional wisdom about these drugs is that they're safe and effective." Andrews and his colleagues examined previous patient studies into the effects of anti-depressants and determined that the benefits of most anti-depressants, even taken at their best, compare poorly to the risks, which include premature death in elderly patients. Anti-depressants are designed to relieve the symptoms of depression by increasing the levels of serotonin in the brain, where it regulates mood. The vast majority of serotonin that the body produces, though, is used for other purposes, including digestion, forming blood clots at wound sites, reproduction and development. What the researchers found is that anti-depressants have negative health effects on all processes normally regulated by serotonin. The findings include these elevated risks: developmental problems in infants problems with sexual stimulation and function and sperm development in adults digestive problems such as diarrhea, constipation, indigestion and bloating abnormal bleeding and stroke in the elderly The authors reviewed three recent studies showing that elderly anti-depressant users are more likely to die than non-users, even after taking other important variables into account. The higher death rates indicate that the overall effect of these drugs on the body is more harmful than beneficial. "Serotonin is an ancient chemical. It's intimately regulating many different processes, and when you interfere with these things you can expect, from an evolutionary perspective, that it's going to cause some harm," Andrews says. Millions of people are prescribed anti-depressants every year, and while the conclusions may seem surprising, Andrews says much of the evidence has long been apparent and available. "The thing that's been missing in the debates about anti-depressants is an overall assessment of all these negative effects relative to their potential beneficial effects," he says. "Most of this evidence has been out there for years and nobody has been looking at this basic issue." In previous research, Andrews and his colleagues had questioned the effectiveness of anti-depressants even for their prescribed function, finding that patients were more likely to suffer relapse after going off their medications as their brains worked to re-establish equilibrium. With even the intended function of anti-depressants in question, Andrews says it is important to look critically at their continuing use. "It could change the way we think about such major pharmaceutical drugs," he says. "You've got a minimal benefit, a laundry list of negative effects -- some small, some rare and some not so rare. The issue is: does the list of negative effects outweigh the minimal benefit?"
Madeleine McCann as she might look aged 9 Photo: Teri Blythe
Detectives released a new “age progression” image of the toddler, which they said showed what she would look like today at the age of nine.
On Wednesday, Britain’s biggest police force said that as a result of evidence uncovered during a review “they now believe there is a possibility Madeleine is still alive”.
Officers have so far identified nearly 200 new items for investigation within historic material and are also “developing what they believe to be genuinely new material”.
Scotland Yard urged Portuguese authorities to reopen the search for her amid the new "investigative opportunities".
Police said the image, created ahead of what would have been her ninth birthday on May 12, had been created in “close collaboration with the family”.
The mosquito can carry dengue and chikungunya viruses
A mosquito that spreads tropical diseases including dengue fever may be poised to invade the UK because of climate change.
The Asian tiger mosquito has already been reported in France and Belgium and could be migrating north as winters become warmer and wetter.
Scientists have urged "wide surveillance" for the biting insect across countries of central and northern Europe, including the UK.
The mosquito can carry dengue and chikungunya viruses, both of which cause high fevers. The infections usually occur in tropical regions of Africa, Asia and South America.
Scientists led by Dr Samantha Martin, from the University of Liverpool, used climate models to predict how changing conditions might affect Asian tiger mosquito distribution.
They wrote in the Journal of the Royal Society Interface: "Mosquito climate suitability has significantly increased over the southern UK, northern France, the Benelux, parts of Germany, Italy, Sicily and the Balkan countries."
The research shows that parts of the UK could become hot-spots of Asian tiger mosquito activity between 2030 and 2050.
The mosquito has been introduced into Europe from Asia via goods shipments, mainly used tyres and bamboo.
Climate change is now shifting conditions suitable for the insect from southern Europe to central north-western areas.
The mosquito could survive in water butts and vases, and may find winter protection in greenhouses, said the researchers.
Eight American soldiers died of overdoses involving heroin, morphine or other opiates during deployments in Afghanistan in 2010 and 2011, according to U.S. Army investigative reports. The overdoses were revealed in documents detailing how the Army investigated a total of 56 soldiers, including the eight who fell victim to overdoses, on suspicion of possessing, using or distributing heroin and other opiates. At the same time, heroin use apparently is on the rise in the Army overall, as military statistics show that the number of soldiers testing positive for heroin has grown from 10 instances in fiscal year 2002 to 116 in fiscal year 2010. Army officials didn't respond to repeated requests for comment on Saturday. But records from the service's Criminal Investigation Command, obtained by the conservative legal group Judicial Watch, provided glimpses into how soldiers bought drugs from Afghan juveniles, an Afghan interpreter and in one case, an employee of a Defense Department contractor, who was eventually fired. The drug use is occurring in a country that is estimated to supply more than 90% of the world's opium, and the Taliban insurgency is believed to be stockpiling the drug to finance their activities, according to a 2009 U.N. study. While the records show some soldiers using heroin, much of the opiate abuse by U.S. soldiers in Afghanistan involves prescription drugs such Percocet, the Army documents show. Judicial Watch obtained the documents under the Freedom of Information of Act and provided them to CNN. Spokesman Col. Gary Kolb of the International Security Assistance Force, the NATO-led command in Afghanistan, verified the documents to CNN on Saturday. One fatal overdose occurred in June 2010 at Forward Operating Base Blessing, after a soldier asked another soldier to buy black tar opium from a local Afghan outside the base's entry control point. The first soldier died after consuming the opium like chewing tobacco and smoking pieces of it in a cigarette, the documents show. The reports even show soldier lingo for the drug -- calling it "Afghani dip" in one case where three soldiers were accused of using the opiate, the Army investigative reports show. The United States has 89,000 troops in Afghanistan. The U.S. death toll since the September 11, 2001, attacks that triggered the war has risen to more than 1,850, including 82 this year, according to the U.S. Department of Defense and U.S. Central Command. Tom Fitton, president of Judicial Watch, said his group was interested in soldiers' drug use partly because the risk was present during the Vietnam War. "You never want to see news of soldiers dying of drug use in Afghanistan," Fitton said. "Our concern is, will the military treat this as the problem that it is, and are the families of the soldiers aware of the added risk in this drug-infested country? "There is a dotted line between the uses. Prescription abuse can easily veer into heroin drug use," Fitton added. "Afghanistan is the capital of this opiate production and the temptation is great there and the opportunity for drug use all the more." The group is concerned that "there hasn't been enough public discussion, and we would encourage the leadership to discuss or talk about this issue more openly," Fitton said. In one case, a soldier bought heroin and the anti-anxiety drug Xanax from five "local national juveniles at multiple locations on Camp Phoenix, Afghanistan, and consumed them," one report states. Soldiers also distributed heroin, Percocet and other drugs among themselves, according to the reports. Another soldier fatally overdosed in December 2010 after taking several drugs, including morphine and codeine, though the drugs were not prescribed for him, the Army documents show. One female soldier broke into the Brigade Medical Supply Office at Forward Operating Base Shank and stole expired prescription narcotics including morphine, Percocet, Valium, fentanyl and lorazepam, the documents show. The investigative reports show soldiers using other drugs, including steroids and marijuana, and even hashish that was sold to U.S. servicemen by the Afghan National Army and Afghan National Police personnel, the reports state.
Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains.
Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant. How could one substance do all that?
Meet the cannabinoid receptor
In the 1980s and 90s, researchers identified cannabinoid receptors, long, ropy proteins that weave themselves into the surfaces of our cells and process THC. They also process other chemicals, many of them naturally occurring in our bodies. Once we'd discovered these receptors, we knew exactly where THC was being processed in our bodies and brains, as well as what physical systems it was affecting. Scattered throughout the body, cannabinoid receptors come in two varieties, called CB1 and CB2 - most of your CB1 receptors are in your brain, and are responsible for that "high" feeling when you smoke pot. CB2 receptors, often associated with the immune system, are found all over the body. THC interacts with both, which is why the drug gives you the giggles and also (when interacting with the immune system) reduces swelling and pain.
Cannabinoid receptors evolved in sea squirts about 500 million years ago; humans and many other creatures inherited ours from a distant ancestor we share with these simple sea creatures. THC binds to receptors in animals as well as humans, with similar effects.
Tasty, tasty, tasty
Cannabis notoriously makes people hungry - even cancer patients who had lost all desire to eat.One study showed that cancer patients who thought food smelled and tasted awful suddenly regained an ability to appreciate food odors after ingesting a THC compound. There are CB1 receptors in your hypothalamus, a part of your brain known to regulate appetite, and your body's own cannabinoids usually send the "I'm hungry" message to them. But when you ingest THC, you artificially boost the amount of cannabinoids sending that message to your hypothalamus, which is why you get the munchies.
Understanding this process has actually led to a new body of research into safe diet drugs that would block those cannabinoid receptors. That way, your hypothalamus wouldn't receive signals from your body telling it to eat, and would reduce hunger cravings in dieters.
What you're forgetting
What's happening in your brain when smoking pot makes you forget what you're saying in the middle of saying it? According to the book Marijuana and Medicine (National Academies Press):
One of the primary effects of marijuana in humans is disruption of short-term memory. That is consistent with the abundance of CB1 receptors in the hippocampus, the brain region most closely associated with memory. The effects of THC resemble a temporary hippocampal lesion.
That's right - smoking a joint creates the effect of temporary brain damage.
What happens is that THC shuts down a lot of the normal neuroprocessing that goes on in your hippocampus, slowing down the memory process. So memories while stoned are often jumpy, as if parts are missing. That's because parts literally are missing: Basically you are saving a lot less information to your memory. It's not that you've quickly forgotten what's happened. You never remembered it at all.
A bit of the old timey wimey
Cannabis also distorts your sense of time. THC affects your brain's dopamine system, creating a stimulant effect. People who are stoned often report feeling excited, anxious, or energetic as a result. Like other stimulants, this affects people's sense of time. Things seem to pass quickly because the brain's clock is sped up. At the same time, as we discussed earlier (if you can remember), the drug slows down your ability to remember things. That's because it interferes with the brain's acetylcholine system, which is part of what helps you store those memories in your hippocampus. You can see that system's pathway through the brain in red in the illustration at left.
In an article io9 published last year about the neuroscience of time, we noted:
The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.
It's almost as if time is speeding up and slowing down at the same time.
Addiction and medicine
Some experts call cannabis a public health menace that's addictive and destroys lives by robbing people of ambition. Other experts call it a cure for everything from insomnia to glaucoma, and advocate its use as a medicine. The former want it to be illegal; the latter want it prescribed by doctors. Still other groups think it should be treated like other intoxicants such as alcohol and coffee - bad if you become dependent on it, but useful and just plain fun in other situations.
What's the truth? Scientists have proven that cannabis does have medical usefulness, and the more we learn the more intriguing these discoveries become. Since the early 1980s, medical researchers have published about how cannabis relieves pressure in the eye, thus easing the symptoms of glaucoma, a disease that causes blindness. THC is also "neuroprotective," meaning in essence that it prevents brain damage. Some studies have suggested that cannabis could mitigate the effects of Alzheimer's for this reason.
At the same time, we know that THC interferes with memory, and it's still uncertain what kinds of long-term effects the drug could have on memory functioning. No one has been able to prove definitively that it does or does not erode memory strength over time. Obviously, smoking it could cause lung damage. And, like the legal intoxicant alcohol, cannabis can become addictive.
Should cannabis be illegal, while alcohol flows? Unfortunately that's not the kind of question that science can answer. Let's leave the moral questions to courts, policymakers and shamans. I'll be off to the side, smoking a joint, thinking about my acetylcholine system and the many uses of the hippocampus.
U.S. Food and Drug Administration issued new safety information about these cholesterol-lowering drugs that are prescribed to millions of Americans to lower the risk of heart disease. If you're among them, you should understand what the FDA's new guidance means for your health. "Before anyone gets too concerned, you should know that statins are so widely used because they have a long track record of safety and effectiveness," says Dr. Mark Taber, a cardiologist with SSM Heart Institute at St. Joseph Health Center. "All in all, statins have a very high benefit to risk ratio. The widespread use of the drugs, when indicated, probably accounts to a significant degree for the improvement in life expectancy in this country." The FDA called attention to the threat of liver damage as a rare side effect of statins and advised that regular liver enzyme testing is no longer considered useful in predicting or preventing liver injury. "Actually, in general they liberalized the follow up needed for liver function tests on patients taking statins, due to the very low incidence of true liver issues," Taber says. The main warnings related to a slightly higher incidence of developing diabetes while on statins, and a poorly substantiated claim that statins could result in cognitive impairment. Taber points out that cognitive problems, such as confusion or memory problems, were not documented in clinical studies, only by patient reports to the FDA website. "By stating these concerns, the FDA is raising awareness about the potential side effects of statins, but cardiologists already know that there are inherent risks, and we monitor patients appropriately to help ensure that side effects do not occur or are dealt with quickly," Taber notes. "If there is any evidence of a side effect that could be problematic, we can change the medication. But the fact remains that it's important to decrease risk of heart disease, and for many people statins are needed when diet and exercise alone don't result in acceptable cholesterol levels." Whenever a new prescription medication is started, you should look over the package insert to learn about potential side effects. Signs of liver damage, for instance, include fatigue, loss of appetite, right upper abdominal pain, dark urine and jaundice. Any of these symptoms should be reported to your doctor for evaluation. It is important to remember that you should not stop taking a medication without consulting your doctor first. Discontinuing use of a prescribed drug can be far more dangerous than the side effect you're worried about. "All the side effects listed by the FDA are rare, and the risk of heart attack is far more concerning," Taber says. "Some patients may need extra monitoring or may need to try more than one statin before we find the optimal choice, but in general statins are very well tolerated and don't cause problems for the people who take them." The advice above is universal when it comes to your health. Concerns should be discussed with your doctor, and decisions should always be made as part of a team approach to creating a healthy life.
John Holliday had been on a higher 40mg dose of cholesterol pills for only a few weeks when he started to lose his concentration. ‘I’d be watching TV and suddenly find myself unable to follow the plot of a drama,’ says John, 52, a telecoms project manager who lives in Southend-on-Sea, Essex, with his wife Jill, 51, and their two children Adam, 20, and Emma, 16. ‘I’d have to read the same page of a book over and over because I couldn’t take any information in. ‘I’d always been known for my amazing memory — I was great on trivia and had total recall of events that happened 20 years ago, but suddenly I couldn’t remember things and my brain felt fuzzy.’ Just like up to seven million other people in Britain, John had been prescribed a statin to lower his blood cholesterol levels. The drugs are credited by the British Heart Foundation as contributing towards the dramatic 50 per cent fall in deaths from heart attacks in the past ten years. But while there is consensus that statins are lifesavers for people who have previously had a heart attack, concern is growing over their debilitating side-effects. They include muscle weakness, depression, sleep disturbance, sexual dysfunction, muscle pain and damage, gastro-intestinal problems, headaches, joint pains and nausea. Now, official bodies here and in the U.S. have ordered that the drugs must carry warnings for cognitive problems, too. Worryingly, it’s claimed GPs are failing to warn patients of the effect statins can have on the mind — meaning they may mistake them for signs of ageing or Alzheimer’s. ‘When I went back to my doctor after six weeks for a blood test, I told him how dreadful I was feeling,’ says John. ‘But he just said all drugs had side-effects and didn’t mention reducing the dose.’ It's claimed GPs are failing to warn patients of the effect statins can have on the mind - meaning they may mistake them for signs of ageing or Alzheimer's Things came to a head when a friend showed John an electrical circuit he’d built for his car. ‘I’d worked with circuits since I was 16 but it made no sense,’ he says. So John insisted on seeing his doctor again and repeated his concerns about his rapidly declining memory. This time the GP told him he could start on another type of statin when he felt well enough, and so John stopped taking the drugs immediately. ‘It took a few months, but gradually my memory returned and I’ve got my concentration back. I can’t say for sure statins caused these problems, but it seems like too much of a coincidence.’ Earlier this year, the Food and Drug Administration (FDA) in the U.S. ordered statins must carry warnings that some users have reported cognitive problems including memory loss, forgetfulness and confusion. This followed a decision by the UK’s Medicines Healthcare Regulatory Agency (MHRA) to add memory problems to the list of possible statin side-effects in late 2009. The FDA said reports about the symptoms were from across all statin products and age groups. Those affected reported feeling fuzzy or unfocused in their thought process — though these were found to be rare and reversible. The FDA also warned, following U.S. research, that patients on statins had a small excess risk of developing Type 2 diabetes — but stressed that the benefits of taking a statin still outweigh this. The MHRA had 2,675 reports for adverse drug reactions connected with statins between 2007 and 2011. Officially, side-effects are rare —affecting only 1 per cent of people on the pills — but some doctors say they are under-reported. Dr Malcolm Kendrick, a GP and author of The Great Cholesterol Con, says he frequently sees patients suffering from mental confusion in his job in hospital intermediary care for the elderly. ‘Many of the patients I see will have been admitted to hospital after a fall or similar crisis,’ he says. ‘If they appear confused I’ll often advise taking them off statins to see if it has any effect — in my experience, about 10 to 15 per cent of people who appeared to have memory problems experienced an improvement in their memory symptoms after being taken off the drug. ‘I had one dramatic case where a lady was admitted to hospital on 40mg a day of simvastatin with such poor memory function her family asked me about power of attorney. 'I suggested taking her off statins and within a week her memory had returned to normal. She went home a fit and independent 83-year-old.’ Dr Kendrick says cholesterol is the main constituent of synapses (structures that allow signals to pass between brain cells and to create new memories) and is essential for brain function. ‘It is still not proven that statins have a significant effect on mortality — it has been calculated that a man who has had a heart attack who took a statin for five years would extend his life by only 14 days. 'Too many statins are being given to people at low risk. ‘Even in the highest risk group you need to treat 200 people a year with statins to delay just one death. 'One day the harm these drugs are doing is going to be obvious — the benefits are being over-hyped and the risks swept under the carpet.’ While Dr Kendrick’s controversial view is in the minority, one large review of 14 studies by the London School of Hygiene and Tropical Medicine, published by the highly respected Cochrane Library last year, concluded there was ‘little evidence’ cholesterol-lowering drugs protect people who are not at risk of heart disease. This review has been criticised by other doctors who say side-effects are rare and that there are still benefits even for people at lower risk who do not have established heart disease. These defenders of statins include Professor Colin Baigent of the Clinical Trial Service at Oxford University, who published research in 2010 showing statins reduced deaths from all causes by 10 per cent over five years. ‘There is relatively little evidence of cognitive impairment — what evidence there is all comes from observational studies. ‘People read about side-effects and then put two and two together and blame the statins for their muscle pain or other health problems — it’s just not reliable evidence. ‘If you look at the best-quality randomised controlled trial where patients don’t know if they are taking a statin or placebo, there is no evidence of memory problems. 'Even the FDA says the risks of cognitive problems are very small and go away when statins are discontinued. ‘We’re in danger of forgetting just how effective these drugs are.’ Dr Dermot Neely of the charity Heart UK, and lead consultant at the Lipid and Metabolic Clinic at the Royal Victoria Infirmary in Newcastle, agrees side-effects with statins are rare. ‘I’ve been dealing with patients on statins since 1987 and I can count on the fingers of one hand the number whose memory symptoms turned out to be caused by statins.’ However, he said he often saw patients who had not been told about side-effects. ‘It’s important GPs are clear about the drugs statins can interact with, such as certain antibiotics, as this can get overlooked. ‘If a patient notices an adverse effect after starting statins, they should discuss this with their GP —but not stop their drugs suddenly because this can be dangerous.’ Sonya Porter, 73, decided to stop taking statins after her memory problems became so bad that she walked away from a cashpoint leaving her money behind. ‘I was permanently fuzzy-headed and just couldn’t seem to concentrate,’ says Sonya, a retired PA from Woking, Surrey. Then I started to get scared I might have Alzheimer’s. After reading about memory problems associated with statins, I thought it was at least a possibility. I decided to come off the pills to see if it made any difference. ‘I didn’t ask my GP, I just did it — I’d rather die of a heart attack than Alzheimer’s disease. Within a month I felt normal again and didn’t have any problems with memory. ‘I’m terrified that I could have been misdiagnosed with Alzheimer’s.’ John Holliday is also reluctant to go back on statins. ‘I wouldn’t rule it out completely — my latest test showed my cholesterol levels have gone up,’ he says. ‘But on balance, I’d rather take my chances with heart disease than feel as confused as that again. It’s all very well living slightly longer — but it’s about quality of life, too.’
A Kansas man was struck by lightning hours after buying three Mega Millions lottery tickets on Thursday, proving in real life the old saying that a gambler is more likely to be struck down from the sky than win the jackpot. Bill Isles, 48, bought three tickets in the record $656 million lottery Thursday at a Wichita, Kansas grocery store. On the way to his car, Isles said he commented to a friend: "I've got a better chance of getting struck by lightning" than winning the lottery. Later at about 9:30 p.m., Isles was standing in the back yard of his Wichita duplex, when he saw a flash and heard a boom -- lightning. "It threw me to the ground quivering," Isles said in a telephone interview on Saturday. "It kind of scrambled my brain and gave me an irregular heartbeat." Isles, a volunteer weather spotter for the National Weather Service, had his portable ham radio with him because he was checking the skies for storm activity. He crawled on the ground to get the radio, which had been thrown from his hand. Isles had been talking to other spotters on the radio and called in about the lightning strike. One of the spotters, a local television station intern, called 911. Isles was taken by ambulance to a hospital and kept overnight for observation. Isles said doctors wanted to make sure his heartbeat was back to normal. He suffered no burns or other physical effects from the strike, which he said could have been worse because his yard has a power line pole and wires overhead. "But for the grace of God, I would have been dead," Isles said. "It was not a direct strike." Isles said he had someone buy him ten more tickets to the Mega Millions lottery on Friday night. While one of the three winning tickets was sold in Kansas, Isles was not a winner. Officials of the Mega Millions lottery, which had the largest prize in U.S. history, said that the odds of winning lottery were about 176 million to one. Americans have a much higher chance of being struck by lightning, at 775,000 to one over the course of a year, depending on the part of the country and the season, according to the National Weather Service. Isles, who is out of work after being laid off last June by a furniture store, said he did once win $2,000 in the lottery and will keep playing. "The next time I will use the radio while sitting in the car," he said
PHOTOGRAPHS of the spot where gangland figure Kevin “Gerbil” Carroll was shot dead were shown to a murder trial jury yesterday. The pictures – shown on day one of the trial – included an image of an Audi with smashed windows. The court was told the car was “subject to a significant degree of examination”. Carroll, 29, was shot in the car park of Asda in Robroyston, Glasgow, in January 2010. Ross Monaghan, 30, has been accused of Carroll’s murder. It is alleged that, while masked and acting with others, Monaghan repeatedly discharged loaded handguns at him, shooting him on the head and body. Monaghan is accused of – while acting with others – attempting to defeat the ends of justice by disposing of a revolver, pistol and ammunition in undergrowth in Coatbridge and Airdrie. It is also claimed a car bearing false number plates was set on fire. Monaghan also faces a number of firearms charges. He denies all the charges against him at the High Court in Glasgow and has incriminated Mr X, who cannot be named for legal reasons, and seven others. The trial, before Lord Brailsford, continues.
Teenagers as young as 11 are modelling sex acts and rape, in the form of daggering, on the dance floor with their peers. Deputy Children's Commissioner Sue Berelowitz said: "there's not a lot separating that kind of behaviour from actual violent, coercive sex." Footage seen by Channel 4 News [see above] shows an under-18s club night in East London. As with all 'under-18s' club nights, everyone is between 11 and 16. Some of the children look much younger. The club is packed. The music: Caribbean dancehall. The dancing style: daggering. It is a style of dancing that any carnival regular will be used to. Aficionados will no doubt, have a more technical description of the style but it mainly involves women bending over and rubbing their backsides up against the men's crotches. During that August weekend in Notting Hill every adult gives it a go. But what's different about this night club is that every child is giving it a go. Spurred on by the DJ, the 'daggering' becomes more enthusiastic, some of it verging on violent. Boys and girls end up on top of each other on the floor simulating sex. Throughout the night someone employed by the club promoter (presumably an adult) is filming it all and uploading it on the club's website via YouTube.
Ryanair is to introduce a six Euro surcharge on all flights purchased in Spain from April 15. This will appear as ‘coste de gestión’ (management charge) and will be added to the final ticket price with the rest of the charges. The charge is a strategy to promote the airline’s new Ryanair Cash Passport, a MasterCard debit card which will give passengers, yes you got it, a six € discount. The card also can be used to take money out of cash machines and to make purchases in stores. Michael O’Leary used the launch of the card to encourage Spanish consumers to get a card ‘As quickly as possible to save the management costs’.
So his choice in on-set accommodation doesn't come as much as a surprise. The actor has allowed cameras into his jaw-dropping $1.1million trailer.
The enormous, 1100 square-foot vehicle is the 44-year-old star's home away from home when he is filming his action blockbusters.
Home away from home: Vin Diesel has allowed cameras inside his $1.1million custom-designed trailer
Luxurious: The trailer features an enormous living area where the movie star can relax in between filming scenes for his blockbuster movies
Fit for a king: Diesel ensures he feels at home in his mansion-on-wheels
The two-storey gold monster has followed Vin around the world. At the moment it is residing on the set of The Chronicles of Riddick: Dead Man Stalking, which the actor is currently filming.
It was even shipped to Puerto Rico where he filmed the latest Fast and the Furious installment.
The spacious trailer has a pop up top floor and features granite countertops in the kitchen.
$70,00 worth of technology, including 3D flat screen TVs and Blu-Ray, keep the actor entertained during those long hours in between scenes.
As well as a media lounge, Diesel also has a private office space and had part of the upstairs turned into a special play area for his kids.
The luxurious trailer was created by Anderson Mobile Estates, who have been commissioned by Mariah Carey, Sharon Stone and Will Smith to make vast vehicles to their extravagant specifications.
Vin's $1.1million trailer is nothing on Smith's whose $2million mansion-on-wheels had to be removed from a New York street during filming of Men In Black 3 after attracting complaints from residents.
Ashton Kutcher also calls one of Anderson's trailers home on the Two and a Half Men set.
Sit back and enjoy the view: Vin's trailer features windows that run the length of the vehicle
Keeping an eye out: High-tech surveillance cameras guard overt he pricey trailer
Vin is currently filming the Chronicles of Riddick film after providing the voice for the video games.
The big screen adaptation sees Riddick fighting against alien predators after being abandoned on a desolate planet.
The sci-fi thriller is due for release next year, while yet another Fast and the Furious film is in the pipeline. It will be the sixth in the franchise, and Diesel's third.
Perfect for Fast and the Furious movie nights: A huge TV screen and surround sound are on display, while the whole trailer is controlled by a central system (remote pad seen on bench)
HOLIDAYMAKERS can pay for the cost of a break in the sun by buying their prescription drugs while abroad. Legally they can purchase their prescribed drugs -- at a fraction of the cost here over the counter -- in Malaga, Marbella , Faro or Lisbon. Those on long term medication and covered by the Drug Payment Scheme, who cough up €132 a month, can particularly benefit. For example, a patient on holiday in Marbella recently bought the three main elements of her prescription. Prescribed for the treatment of high blood pressure, high cholesterol and to reduce risk of cardiovascular problems they cost her almost four times as much in Dublin as in Spain. The products -- Lipitor, Cozaar Comp and Tritace -- in their generic form came to €108.13 in Dublin for a month's supply. In Marbella the same medicines are sold under a different name for €63.72 for two months' supply. That is a saving of €152.54 for two months. On that basis a six month prescription for the three tablets would cost €648.78 in Dublin as against €191.16 in Spain -- a staggering saving of €457.62. The Irish Medicines Board and the Revenue Commissioners both confirmed that medication, prescription and non prescription, bought for personal use within the EU or outside may be brought back in to the State legally. imported They agreed that travellers are permitted to import on their person or in their baggage "a reasonable amount of such medicines for personal use". "Anyone entering the State may bring their personal medication with them and that personal medication should be no more than any amount that may be obtained on a prescription, for example up to a three months supply. "Any amount being imported above a level that would be considered to be normal personal use, could be considered to be a commercial quantity and for business purposes." This "personal use" exemption does not apply to products imported by other means, ie. in the post, by express couriers or in merchandise. Revenue said that the law of the country where you are visiting will dictate whether your Irish prescription will be accepted or whether you will require a doctor's prescription from that country. They advised it is always a good idea to have a copy of your prescription in your possession so that customs officers can verify it by contacting the dispensing pharmacy and the doctor who issued it.
Researchers have established a direct link between the number of friends you have on Facebook and the degree to which you are a "socially disruptive" narcissist, confirming the conclusions of many social media sceptics. People who score highly on the Narcissistic Personality Inventory questionnaire had more friends on Facebook, tagged themselves more often and updated their newsfeeds more regularly. The research comes amid increasing evidence that young people are becoming increasingly narcissistic, and obsessed with self-image and shallow friendships. The latest study, published in the journal Personality and Individual Differences, also found that narcissists responded more aggressively to derogatory comments made about them on the social networking site's public walls and changed their profile pictures more often. A number of previous studies have linked narcissism with Facebook use, but this is some of the first evidence of a direct relationship between Facebook friends and the most "toxic" elements of narcissistic personality disorder. Researchers at Western Illinois University studied the Facebook habits of 294 students, aged between 18 and 65, and measured two "socially disruptive" elements of narcissism – grandiose exhibitionism (GE) and entitlement/exploitativeness (EE). GE includes ''self-absorption, vanity, superiority, and exhibitionistic tendencies" and people who score high on this aspect of narcissism need to be constantly at the centre of attention. They often say shocking things and inappropriately self-disclose because they cannot stand to be ignored or waste a chance of self-promotion. The EE aspect includes "a sense of deserving respect and a willingness to manipulate and take advantage of others". The research revealed that the higher someone scored on aspects of GE, the greater the number of friends they had on Facebook, with some amassing more than 800. Those scoring highly on EE and GG were also more likely to accept friend requests from strangers and seek social support, but less likely to provide it, according to the research. Carol Craig, a social scientist and chief executive of the Centre for Confidence and Well-being, said young people in Britain were becoming increasingly narcissistic and Facebook provided a platform for the disorder. "The way that children are being educated is focussing more and more on the importance of self esteem – on how you are seen in the eyes of others. This method of teaching has been imported from the US and is 'all about me'. "Facebook provides a platform for people to self-promote by changing profile pictures and showing how many hundreds of friends you have. I know of some who have more than 1,000." Dr Viv Vignoles, senior lecturer in social psychology at Sussex University, said there was "clear evidence" from studies in America that college students were becoming increasingly narcissistic. But he added: "Whether the same is true of non-college students or of young people in other countries, such as the UK, remains an open question, as far as I know. "Without understanding the causes underlying the historical change in US college students, we do not know whether these causes are factors that are relatively specific to American culture, such as the political focus on increasing self-esteem in the late 80s and early 90s or whether they are factors that are more general, for example new technologies such as mobile phones and Facebook." Vignoles said the correlational nature of the latest study meant it was difficult to be certain whether individual differences in narcissism led to certain patterns of Facebook behaviour, whether patterns of Facebook behaviour led to individual differences in narcissism, or a bit of both. Christopher Carpenter, who ran the study, said: "In general, the 'dark side' of Facebook requires more research in order to better understand Facebook's socially beneficial and harmful aspects in order to enhance the former and curtail the latter. "If Facebook is to be a place where people go to repair their damaged ego and seek social support, it is vitally important to discover the potentially negative communication one might find on Facebook and the kinds of people likely to engage in them. Ideally, people will engage in pro-social Facebooking rather than anti-social me-booking."
One day in 1999 Duane Graveline, then a 68-year-old former NASA astronaut, returned home from his morning walk in Merritt Island, Fla., and could not remember where he was. His wife stepped outside, and he greeted her as a stranger. When Graveline’s memory returned some six hours later in the hospital, he racked his brain to figure out what might have caused this terrifying bout of amnesia. Only one thing came to mind: he had recently started taking the statin drug Lipitor. Cholesterol-lowering statins such as Lipitor, Crestor and Zocor are the most widely prescribed medications in the world, and they are credited with saving the lives of many heart disease patients. But recently a small number of users have voiced concerns that the drugs elicit unexpected cognitive side effects, such as memory loss, fuzzy thinking and learning difficulties. Hundreds of people have registered complaints with MedWatch, the U.S. Food and Drug Administration’s adverse drug reaction database, but few studies have been done and the results are inconclusive. Nevertheless, many experts are starting to believe that a small percentage of the population is at risk, and they are calling for increased public awareness of the possible cognitive side effects of statins—symptoms that may be misdiagnosed as dementia in the aging patients who take them. Fat and the Brain It is not crazy to connect cholesterol-modifying drugs with cognition; after all, one quarter of the body’s cholesterol is found in the brain. Cholesterol is a waxy substance that, among other things, provides structure to the body’s cell membranes. High levels of cholesterol in the blood create a risk for heart disease, because the molecules that transport cholesterol can damage arteries and cause blockages. In the brain, however, cholesterol plays a crucial role in the formation of neuronal connections—the vital links that underlie memory and learning. Quick thinking and rapid reaction times depend on cholesterol, too, because the waxy molecules are the building blocks of the sheaths that insulate neurons and speed up electrical transmissions. “We can’t understand how a drug that affects such an important pathway would not have adverse reactions,” says Ralph Edwards, former director of the World Health Organization’s drug-monitoring center in Uppsala, Sweden. Two small trials published in 2000 and 2004 by Matthew Muldoon, a clinical pharmacologist at the University of Pittsburgh, seem to suggest a link between statins and cognitive problems. The first, which enrolled 209 high-cholesterol subjects, reported that participants taking placebo pills improved more on repeated tests of attention and reaction time taken over the course of six months—presumably getting better because of practice, as people typically do. Subjects who were on statins, however, did not show the normal improvement—suggesting their learning was impaired. The second trial reported similar findings. And a study published in 2003 in Reviews of Therapeutics noted that among 60 statin users who had reported memory problems to MedWatch, more than half said their symptoms improved when they stopped taking the drugs. But other studies have found no significant link between statins and memory problems. Larry Sparks, director of the Laboratory for Neurodegenerative Research at the Sun Health Research Institute in Sun City, Ariz., goes so far as to say that “you’ve got a better chance of buying a winning lottery ticket, walking outside and getting hit by lightning and dying” than you do of suffering a cognitive side effect from statins. Vulnerable Genes? Many experts agree that for most people the risk is quite low, but they are beginning to believe the effects are real. “A subset of the population is vulnerable,” argues Joe Graedon, co-founder of the consumer advocacy Web site the People’s Pharmacy, which has collected hundreds of reports of cognitive-related statin side effects in the past decade. Some researchers believe these people have a genetic profile that puts them at risk.
When the US Food and Drug Administration told the makers of cholesterol-lowering statins to add new side effect warnings to their labels last week, many of the 40 million statin users may have been unaware of the extent of the risks associated with these drugs that have been touted by some cardiologists to be safer than aspirin. No question, statins -- which include Lipitor (atorvastatin), Zocor (simvastatin), and Crestor (rosuvastatin) -- are relatively safe drugs, and they’ve saved thousands of lives over the past 20 years, particularly in men with established heart disease. But like any drug they can cause problems in some, including muscle aches, an increased risk of diabetes, and, gaining recent attention, memory loss. University of California-San Diego researcher Beatrice Golomb published a paper two years ago describing 171 statin users who reported that they had developed memory problems and dementia-like symptoms that the statin users attributed to their use of the medications. The vast majority experienced an improvement in their symptoms after stopping the drugs and many saw their symptoms return after going back on statins. Robert Grindell, a state employee from Makinen, Minn., told me his short-term memory began to deteriorate after he started taking Zocor in his early 50s. (He contacted Golomb after hearing about her research.) “My co-workers told me I was coming in to ask them the same question three times in one day,” he said. “I had a CT scan to determine if I had a stroke, but it came back fine; the next day, I couldn’t even remember where I had the test performed.” After learning that Zocor caused memory problems, Grindell decided to go off it and said within a few days he noticed an improvement in his memory, not having to glance down several times at a printed phone number as he dialed it to remember the digits. Unfortunately, the exact incidence of these memory problems isn’t known. Manufacturer-sponsored clinical trials show that they occur in fewer than 1 percent of users, but statin researcher Dr. Paul Thompson, chief of cardiololgy at Hartford Hospital, said the real incidence is probably much higher. He has a study expected to be published sometime this year that measured cognitive effects in statin users compared with those on placebos that he said will provide a better estimate; the findings can’t be disclosed until the study is published. The diabetes risks of statins are more well-established. One review study published last year calculated an extra two cases of type 2 diabetes in every 1,000 patients who took a high-dose statin (80 milligrams per day) compared with those who took a lower dose (20 to 40 milligrams). And one clinical trial found that statin users had about a 25 percent increased risk of developing diabetes over a two-year period compared with those who took placebos. Experts, though, agree that in people at high risk for heart disease, the increased diabetes risk is outweighed by the statin’s protection against heart attacks and deaths from any cause. The danger of muscle destruction from statins -- which can damage the liver and kidneys -- is also clear but slight. According to Thompson, about 1 in every 1,000 statin users will develop severely elevated levels of the enzyme creatine kinase, which indicates muscle death, and only 1 in 10 million die from developing an extremely severe case of the condition called rhabdomyolysis. Muscle aches are far more common: occuring in about 1 in 10 users, according to Thompson. “It seems to be more common in people who do a lot of exercise.” In fact, a study he conducted found that marathon runners taking statins developed a greater increase in creatine kinase right after their race compared with runners who weren’t on statins. “We also see more muscle aches in older people and women since they have less muscle mass,” he said. Lowering the statin dose or switching to a different statin doesn’t always help, Thompson said. “In our studies, those who develop statin myalgia tend to get it again and again; they’re body may get sensitized to statins.” There may also be a genetic component, with statin muscle aches occuring more often in those whose parents also had them. And there may be a link between memory loss and muscle aches. “In our database, the majority of patients who had cognitive problems also had muscle problems,” Golomb said. She recommends that those who are having memory loss or muscle aches speak to their doctor about going off statins -- especially if they’re not in a high-risk group for heart attacks. Those who get the most benefits are men under 65 who’ve already had a heart attack, she said. Women, elderly people, and those without heart disease get much smaller benefits from statins, and it’s unclear whether the drugs extend their lives. “Many patients have told me that their doctor said going off statins would kill them,” Golomb said, “but that’s not an accurate representation of the evidence.”
Two brothers who tried to flood the north-east of Scotland with heroin and cocaine have been jailed. Paul and Anthony Smith were jailed for more than five years each after they admitted transporting a "significant" amount of class-A drugs into Aberdeen and Shetland. The pair, originally from Liverpool, were sentenced at the High Court in Aberdeen on Monday after previously admitting being involved in the supply of heroin and cocaine between October 2010 and February last year. Detective Inspector Alex Dowall said: "These men were intent on flooding the streets of Aberdeen and Shetland with class-A drugs and were willing to take great risks in the process in order to turn a profit. "Ultimately though, as their sentences today prove, the risk is much greater than the potential reward." Anthony Smith, 30, was jailed for five years and seven months while his 27-year-old sibling received a sentence of five years and two months. Det Insp Dowall added: "This was a complex inquiry across two countries and three force areas and it should serve as a warning to others intent on bringing drugs into the north-east that it will not be tolerated. "Operation Limehouse is an example of Grampian Police working closely with other police forces across the UK in order to target those suspected of committing drugs offences. "It must also be said that the assistance provided by local communities in Aberdeen and Shetland in bring these individuals to justice was invaluable."
Scientists believe they are closer to understanding how taking cannabis disrupts short-term memory. The Canadian team from Ottawa University narrowed the effect down to a particular type of brain cell called an astrocyte. Writing in the journal Cell, they said it might be possible to block it in medicines based on cannabis. A UK researcher said it could reveal more about natural brain chemicals. Cannabis floods the brain with a host of chemicals which mimic one of its own subtle signalling systems, leading to pronounced changes in mood and memory. Scientists are trying to harness the power of these chemicals, called cannabinoids, in pharmaceuticals aimed at conditions such as multiple sclerosis and chronic pain. The doses of cannabinoid are carefully controlled to avoid the "high" feeling. The work by the Ottawa University researchers may shed light on how one of the best known cannabinoids, THC, acts on the brain. Memory matters Their work suggests that, when it comes to affecting memory, THC is acting not, as might be expected, on the brain's neurons, but on a brain cell called an astrocyte. Continue reading the main story “ Start Quote We may find a way to deal with working memory problems in Alzheimer's.” Dr Xia Zhang They bred mice whose astrocytes could not be affected by THC, and found that their spatial memory was unaffected by the dose. This discovery could help drug companies reduce the risk of unwanted side effects when using THC in their products, they suggested. However, possibly more importantly, it could shed light on the brain's own chemical pathways, the "endocannabinoid" system. Dr Xia Zhang, one of the researchers, said: "Just about any physiological function you can think of in the body, it's likely at some point endocannabinoids are involved." Understanding how this system works could lead to ways to make it work better, he suggested. "We may find a way to deal with working memory problems in Alzheimer's," he said. Prof Heather Ashton, from the University of Newcastle, said that memory problems were an established feature of cannabis use, and understanding the mechanism behind them was "interesting". She said: "When someone is taking cannabis, in some cases you find that they cannot even remember starting a sentence by the time they reach the end." But she agreed that the practical benefits of such research might ultimately lie in a better understanding of the body's own endocannabinoid system, rather than the effects of cannabis itself.
Drugs gang executed one of their dealer's and then blew up his house to cover-up the murder, a court heard this afternoon. Colliston Edwards, 38, of no fixed address and Andre Johnson, 25, also of no fixed address are accused of shooting Leroy Burnett, 43, after he kept back some of their money from drugs deals. Max Walter, 21, of no fixed address was then recruited by the pair to blow-up his house in Crichton Road, Battersea the Old Bailey heard. Mr Burnett was allegedly a low level drug supplier, who dealt drugs in Wandsworth Road and the Nine Elms area on behalf of Edwards. Edwards, whose street name is Lousy, was allegedly a drug dealer who commuted between Doncaster and South London and worked in a team with Johnson, known as Tallman. The court heard that Lousy had two mobile phones and gave out the numbers to his customers, travelling to their homes to sell the drugs. He allegedly expected Mr Burnett to carry out sales and look after his phones whilst he was away in Doncaster, but problems arose when Mr Burnett started miscounting money owed to him. Prosecuting, Aftab Jaffbrjee said: "There was simply no reason other than this pernicious deed of drugs supply to cost Leroy his life. Ads by Google Build Eco Friendly Visit us Today for Carbon Reduction Eco Tips for Construction Industry! www.CutCarbon.info Election Boundary Changes Constituencies are changing. Have your say on our report, Autumn 2013 independent.gov.uk/boundarychanges "He was executed in his home having been shot in the head at point blank range. There was nothing else that accounted in his life for such a brutal attack. "Walter then blew up the entire house causing destruction to the building and the street." Edwards and Johnson are both on trial for joint enterprise of murder and intending to pervert the course of justice. They deny having anything to do with the murder or the cover-up. Walter has pleaded guilty to perverting the course of justice and arson, but denies being reckless as to whether life was endangered. The trial which opened this afternoon is expected to last six weeks.
federal jury found Christopher Bryan Ablett, a/k/a “Stoney,” a member of the Modesto Chapter of the Mongols outlaw motorcycle gang, guilty of all four felonies with which he was charged including murder in aid of racketeering, assault with a deadly weapon in aid of racketeering, using a firearm during a crime of violence, and using a firearm causing murder during a crime of violence, United States Attorney Melinda Haag announced. The charges stemmed from the defendant’s gang-related murder of Mark “Papa” Guardado, the president of the San Francisco Chapter of the Hells Angels, on September 2, 2008, at 24th Street and Treat Avenue in the Mission District of San Francisco. Evidence at trial showed that Ablett traveled to San Francisco to visit a friend. He was armed with a foot-long military knife and a .357 magnum revolver. Ablett brought with him a Mongols full-patch vest and t-shirt that only a full member of the Mongols is allowed to wear. According to testimony from Bureau of Alcohol Tobacco Firearms and Explosives (ATF) gang expert Special Agent John Ciccone, and former Mongols undercover ATF Special Agent Darrin Kozlowski who infiltrated the gang, the Mongols are an organized criminal motorcycle gang whose primary rival is the Hells Angels motorcycle gang. When word traveled to Guardado that the defendant was wearing a Mongols patch shirt in a bar in the Mission, Guardado went to the street outside the bar and approached Ablett. A fight broke out during which Ablett stabbed Guardado four times and shot him twice, killing him. According to the testimony of FBI Special Agent Jacob Millspaugh, the case agent, the defendant’s phone records showed that he spent the next several hours calling people who were identified as members of the Mongols—showing that he was reaching out as part of the Mongols communication network. The jury rejected the defendant’s defenses of self-defense, defense of his friends, and heat of passion after the defendant took the stand and testified. The jury also found that the defendant murdered Guardado to maintain or increase his position in the Mongols gang, and that the Mongols engaged in racketeering activity. Ablett is scheduled to be sentenced on May 15, 2012. He faces a possible sentence of three terms of life in prison plus 10 mandatory consecutive years, a $1 million fine, and five years of supervised release. Specifically, for the charge of murder in aid of racketeering, in violation of 18 United StatesC. § 1959, Ablett faces a mandatory minimum sentence of life without parole. For the charge of assault with a deadly weapon in aid of racketeering, in violation of 18 United StatesC. § 1959, Ablett faces a maximum sentence of 20 years in prison. For the charge of using a firearm during a crime of violence, in violation of 18 United StatesC. § 924(c), Ablett faces a maximum sentence of life in prison. And for the charge of using a firearm causing murder during a crime of violence, in violation of 18 United StatesC. § 924(j), Ablett faces a maximum sentence of life in prison. However, any sentence following conviction would be imposed by the court after consideration of the United States Sentencing Guidelines and the federal statute governing the imposition of a sentence, 18 United StatesC. § 3553. The case was prosecuted by former Assistant United States Attorney Christine Wong, Assistant United States Attorneys Kathryn Haun, Wilson Leung and William Frentzen, paralegal specialist Lili ArauzHaase, legal techs Marina Ponomarchuk, Daniel Charlier-Smith, and Ponly Tu, all of the Organized Crime Strike Force and Violent Crime Section of the United States Attorney’s Office for the Northern District of California. The case was investigated by the Federal Bureau of Investigation, the Bureau of Alcohol Tobacco Firearms and Explosives, and the San Francisco Police Department.
Between 2004 and 2007 there were 282 cocaine-related deaths
In the same period there were 376,000 users per year aged 25 or less
And there were 133,000 over 35s using every year during that time
Men are more than twice as likely to die from cocaine than females
Almost one in 10 Britons aged 15-64 have taken cocaine (and one in seven aged 15-34) - the highest in Europe
Spain next, with 8.3 per cent and Ireland fourth with 8.2 per cent
Usage between 15-34 increased by 50 per cent since 2003
Cannabis still more widely used than cocaine: 75.5million Europeans have smoked (one in four)
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A bit of the old timey wimey
