Scotland Yard has urged Portuguese authorities to reopen the search for Madeleine McCann as detectives said there are 195 potential leads to finding her alive. The detective leading the Metropolitan Police review said the case can still be solved before officers released a picture of what she might now look like as a nine-year-old. Detective Chief Inspector Andy Redwood said he believes her disappearance was a stranger abduction, as he said there are 195 "investigative opportunities". Police refused to say what evidence they had uncovered to suggest Madeleine is alive. Mr Redwood confirmed that his team of more than 30 officers involved in the case had been out to Portugal seven times, including a visit to the family's holiday flat in Praia da Luz. It will be five years ago next week since the three-year-old went missing as her parents, Kate and Gerry McCann, dined with friends nearby. A spokesman for the McCanns said the family was pleased with the image. Mr Redwood said his 37 officers had dealt with 40,000 pieces of information but the "primacy still sits in Portugal" in the attempt to find her. Commander Simon Foy said: "Most significantly, the message we want to bring to you is that, on the evidence, there is a possibility that she is alive and we desperately need your help today to appeal directly to the public for information to support our investigation." Mr Redwood said "evidence that she is alive stems from the forensic view of the timeline" that there was the opportunity for her to be taken. Investigations show "there do appear to be gaps", he added. Detectives in Portugal are also understood to want the case reopened but must gain judicial approval via the courts.
Companies that do not do enough to keep their websites secure are to be named and shamed to help improve security. The list of good and bad sites will be published regularly by the non-profit Trustworthy Internet Movement (TIM). A survey carried out to launch the group found that more than 52% of sites tested were using versions of security protocols known to be compromised. The group will test websites to see how well they have implemented basic security software. Security fundamentals The group has been set up by security experts and entrepreneurs frustrated by the slow pace of improvements in online safety. "We want to stimulate some initiatives and get something done," said TIM's founder Philippe Courtot, serial entrepreneur and chief executive of security firm Qualys. He has bankrolled the group with his own money. TIM has initially focused on a widely used technology known as the Secure Sockets Layer (SSL). Experts recruited to help with the initiative include SSL's inventor Dr Taher Elgamal; "white hat" hacker Moxie Marlinspike who has written extensively about attacking the protocol; and Michael Barrett, chief security officer at Paypal. Continue reading the main story “ Start Quote Everyone is now going to be able to see who has a good grade and who has a bad grade” Philippe Courtot Many websites use SSL to encrypt communications between them and their users. It is used to protect credit card numbers and other valuable data as it travels across the web. "SSL is one of the fundamental parts of the internet," said Mr Courtot. "It's what makes it trustworthy and right now it's not as secure as you think." Compromised certificates TIM plans a two-pronged attack on SSL. The first part would be to run automated tools against websites to test how well they had implemented SSL, said Mr Courtot. "We'll be making it public," he added. "Everyone is now going to be able to see who has a good grade and who has a bad grade." Early tests suggest that about 52% of sites checked ran a version of SSL known to be compromised. Companies who have done a bad job will be encouraged to improve and upgrade their implementations so it gets safer to use those sites. The second part of the initiative concerns the running of the bodies, known as certificate authorities, which guarantee that a website is what it claims to be. TIM said it would work with governments, industry bodies and companies to check that CAs are well run and had not been compromised. "It's a much more complex problem," said Mr Courtot. In 2011, two certificate authorities, DigiNotar and GlobalSign were found to have been compromised. In some cases this meant attackers eavesdropped on what should have been a secure communications channel. Steve Durbin, global vice president of the Information Security Forum which represents security specialists working in large corporations, said many of its members took responsibility for making sure sites were secure. "You cannot just say 'buyer beware'," he said. "That's not good enough anymore. They have a real a duty of care." He said corporations were also increasingly conscious of their reputation for providing safe and secure services to customers. Data breaches, hack attacks and poor security were all likely to hit share prices and could mean they lose customers, he noted.
Commonly prescribed anti-depressants appear to be doing patients more harm than good, say researchers who have published a paper examining the impact of the medications on the entire body. See Also: Health & Medicine Pharmacology Birth Defects Mental Health Research Mind & Brain Depression Disorders and Syndromes Psychiatry Reference COX-2 inhibitor Psychoactive drug Seasonal affective disorder Anti-obesity drug "We need to be much more cautious about the widespread use of these drugs," says Paul Andrews, an evolutionary biologist at McMaster University and lead author of the article, published recently in the online journal Frontiers in Psychology. "It's important because millions of people are prescribed anti-depressants each year, and the conventional wisdom about these drugs is that they're safe and effective." Andrews and his colleagues examined previous patient studies into the effects of anti-depressants and determined that the benefits of most anti-depressants, even taken at their best, compare poorly to the risks, which include premature death in elderly patients. Anti-depressants are designed to relieve the symptoms of depression by increasing the levels of serotonin in the brain, where it regulates mood. The vast majority of serotonin that the body produces, though, is used for other purposes, including digestion, forming blood clots at wound sites, reproduction and development. What the researchers found is that anti-depressants have negative health effects on all processes normally regulated by serotonin. The findings include these elevated risks: developmental problems in infants problems with sexual stimulation and function and sperm development in adults digestive problems such as diarrhea, constipation, indigestion and bloating abnormal bleeding and stroke in the elderly The authors reviewed three recent studies showing that elderly anti-depressant users are more likely to die than non-users, even after taking other important variables into account. The higher death rates indicate that the overall effect of these drugs on the body is more harmful than beneficial. "Serotonin is an ancient chemical. It's intimately regulating many different processes, and when you interfere with these things you can expect, from an evolutionary perspective, that it's going to cause some harm," Andrews says. Millions of people are prescribed anti-depressants every year, and while the conclusions may seem surprising, Andrews says much of the evidence has long been apparent and available. "The thing that's been missing in the debates about anti-depressants is an overall assessment of all these negative effects relative to their potential beneficial effects," he says. "Most of this evidence has been out there for years and nobody has been looking at this basic issue." In previous research, Andrews and his colleagues had questioned the effectiveness of anti-depressants even for their prescribed function, finding that patients were more likely to suffer relapse after going off their medications as their brains worked to re-establish equilibrium. With even the intended function of anti-depressants in question, Andrews says it is important to look critically at their continuing use. "It could change the way we think about such major pharmaceutical drugs," he says. "You've got a minimal benefit, a laundry list of negative effects -- some small, some rare and some not so rare. The issue is: does the list of negative effects outweigh the minimal benefit?"
Madeleine McCann as she might look aged 9 Photo: Teri Blythe
Detectives released a new “age progression” image of the toddler, which they said showed what she would look like today at the age of nine.
On Wednesday, Britain’s biggest police force said that as a result of evidence uncovered during a review “they now believe there is a possibility Madeleine is still alive”.
Officers have so far identified nearly 200 new items for investigation within historic material and are also “developing what they believe to be genuinely new material”.
Scotland Yard urged Portuguese authorities to reopen the search for her amid the new "investigative opportunities".
Police said the image, created ahead of what would have been her ninth birthday on May 12, had been created in “close collaboration with the family”.
The mosquito can carry dengue and chikungunya viruses
A mosquito that spreads tropical diseases including dengue fever may be poised to invade the UK because of climate change.
The Asian tiger mosquito has already been reported in France and Belgium and could be migrating north as winters become warmer and wetter.
Scientists have urged "wide surveillance" for the biting insect across countries of central and northern Europe, including the UK.
The mosquito can carry dengue and chikungunya viruses, both of which cause high fevers. The infections usually occur in tropical regions of Africa, Asia and South America.
Scientists led by Dr Samantha Martin, from the University of Liverpool, used climate models to predict how changing conditions might affect Asian tiger mosquito distribution.
They wrote in the Journal of the Royal Society Interface: "Mosquito climate suitability has significantly increased over the southern UK, northern France, the Benelux, parts of Germany, Italy, Sicily and the Balkan countries."
The research shows that parts of the UK could become hot-spots of Asian tiger mosquito activity between 2030 and 2050.
The mosquito has been introduced into Europe from Asia via goods shipments, mainly used tyres and bamboo.
Climate change is now shifting conditions suitable for the insect from southern Europe to central north-western areas.
The mosquito could survive in water butts and vases, and may find winter protection in greenhouses, said the researchers.
Eight American soldiers died of overdoses involving heroin, morphine or other opiates during deployments in Afghanistan in 2010 and 2011, according to U.S. Army investigative reports. The overdoses were revealed in documents detailing how the Army investigated a total of 56 soldiers, including the eight who fell victim to overdoses, on suspicion of possessing, using or distributing heroin and other opiates. At the same time, heroin use apparently is on the rise in the Army overall, as military statistics show that the number of soldiers testing positive for heroin has grown from 10 instances in fiscal year 2002 to 116 in fiscal year 2010. Army officials didn't respond to repeated requests for comment on Saturday. But records from the service's Criminal Investigation Command, obtained by the conservative legal group Judicial Watch, provided glimpses into how soldiers bought drugs from Afghan juveniles, an Afghan interpreter and in one case, an employee of a Defense Department contractor, who was eventually fired. The drug use is occurring in a country that is estimated to supply more than 90% of the world's opium, and the Taliban insurgency is believed to be stockpiling the drug to finance their activities, according to a 2009 U.N. study. While the records show some soldiers using heroin, much of the opiate abuse by U.S. soldiers in Afghanistan involves prescription drugs such Percocet, the Army documents show. Judicial Watch obtained the documents under the Freedom of Information of Act and provided them to CNN. Spokesman Col. Gary Kolb of the International Security Assistance Force, the NATO-led command in Afghanistan, verified the documents to CNN on Saturday. One fatal overdose occurred in June 2010 at Forward Operating Base Blessing, after a soldier asked another soldier to buy black tar opium from a local Afghan outside the base's entry control point. The first soldier died after consuming the opium like chewing tobacco and smoking pieces of it in a cigarette, the documents show. The reports even show soldier lingo for the drug -- calling it "Afghani dip" in one case where three soldiers were accused of using the opiate, the Army investigative reports show. The United States has 89,000 troops in Afghanistan. The U.S. death toll since the September 11, 2001, attacks that triggered the war has risen to more than 1,850, including 82 this year, according to the U.S. Department of Defense and U.S. Central Command. Tom Fitton, president of Judicial Watch, said his group was interested in soldiers' drug use partly because the risk was present during the Vietnam War. "You never want to see news of soldiers dying of drug use in Afghanistan," Fitton said. "Our concern is, will the military treat this as the problem that it is, and are the families of the soldiers aware of the added risk in this drug-infested country? "There is a dotted line between the uses. Prescription abuse can easily veer into heroin drug use," Fitton added. "Afghanistan is the capital of this opiate production and the temptation is great there and the opportunity for drug use all the more." The group is concerned that "there hasn't been enough public discussion, and we would encourage the leadership to discuss or talk about this issue more openly," Fitton said. In one case, a soldier bought heroin and the anti-anxiety drug Xanax from five "local national juveniles at multiple locations on Camp Phoenix, Afghanistan, and consumed them," one report states. Soldiers also distributed heroin, Percocet and other drugs among themselves, according to the reports. Another soldier fatally overdosed in December 2010 after taking several drugs, including morphine and codeine, though the drugs were not prescribed for him, the Army documents show. One female soldier broke into the Brigade Medical Supply Office at Forward Operating Base Shank and stole expired prescription narcotics including morphine, Percocet, Valium, fentanyl and lorazepam, the documents show. The investigative reports show soldiers using other drugs, including steroids and marijuana, and even hashish that was sold to U.S. servicemen by the Afghan National Army and Afghan National Police personnel, the reports state.
Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains.
Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant. How could one substance do all that?
Meet the cannabinoid receptor
In the 1980s and 90s, researchers identified cannabinoid receptors, long, ropy proteins that weave themselves into the surfaces of our cells and process THC. They also process other chemicals, many of them naturally occurring in our bodies. Once we'd discovered these receptors, we knew exactly where THC was being processed in our bodies and brains, as well as what physical systems it was affecting. Scattered throughout the body, cannabinoid receptors come in two varieties, called CB1 and CB2 - most of your CB1 receptors are in your brain, and are responsible for that "high" feeling when you smoke pot. CB2 receptors, often associated with the immune system, are found all over the body. THC interacts with both, which is why the drug gives you the giggles and also (when interacting with the immune system) reduces swelling and pain.
Cannabinoid receptors evolved in sea squirts about 500 million years ago; humans and many other creatures inherited ours from a distant ancestor we share with these simple sea creatures. THC binds to receptors in animals as well as humans, with similar effects.
Tasty, tasty, tasty
Cannabis notoriously makes people hungry - even cancer patients who had lost all desire to eat.One study showed that cancer patients who thought food smelled and tasted awful suddenly regained an ability to appreciate food odors after ingesting a THC compound. There are CB1 receptors in your hypothalamus, a part of your brain known to regulate appetite, and your body's own cannabinoids usually send the "I'm hungry" message to them. But when you ingest THC, you artificially boost the amount of cannabinoids sending that message to your hypothalamus, which is why you get the munchies.
Understanding this process has actually led to a new body of research into safe diet drugs that would block those cannabinoid receptors. That way, your hypothalamus wouldn't receive signals from your body telling it to eat, and would reduce hunger cravings in dieters.
What you're forgetting
What's happening in your brain when smoking pot makes you forget what you're saying in the middle of saying it? According to the book Marijuana and Medicine (National Academies Press):
One of the primary effects of marijuana in humans is disruption of short-term memory. That is consistent with the abundance of CB1 receptors in the hippocampus, the brain region most closely associated with memory. The effects of THC resemble a temporary hippocampal lesion.
That's right - smoking a joint creates the effect of temporary brain damage.
What happens is that THC shuts down a lot of the normal neuroprocessing that goes on in your hippocampus, slowing down the memory process. So memories while stoned are often jumpy, as if parts are missing. That's because parts literally are missing: Basically you are saving a lot less information to your memory. It's not that you've quickly forgotten what's happened. You never remembered it at all.
A bit of the old timey wimey
Cannabis also distorts your sense of time. THC affects your brain's dopamine system, creating a stimulant effect. People who are stoned often report feeling excited, anxious, or energetic as a result. Like other stimulants, this affects people's sense of time. Things seem to pass quickly because the brain's clock is sped up. At the same time, as we discussed earlier (if you can remember), the drug slows down your ability to remember things. That's because it interferes with the brain's acetylcholine system, which is part of what helps you store those memories in your hippocampus. You can see that system's pathway through the brain in red in the illustration at left.
In an article io9 published last year about the neuroscience of time, we noted:
The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.
It's almost as if time is speeding up and slowing down at the same time.
Addiction and medicine
Some experts call cannabis a public health menace that's addictive and destroys lives by robbing people of ambition. Other experts call it a cure for everything from insomnia to glaucoma, and advocate its use as a medicine. The former want it to be illegal; the latter want it prescribed by doctors. Still other groups think it should be treated like other intoxicants such as alcohol and coffee - bad if you become dependent on it, but useful and just plain fun in other situations.
What's the truth? Scientists have proven that cannabis does have medical usefulness, and the more we learn the more intriguing these discoveries become. Since the early 1980s, medical researchers have published about how cannabis relieves pressure in the eye, thus easing the symptoms of glaucoma, a disease that causes blindness. THC is also "neuroprotective," meaning in essence that it prevents brain damage. Some studies have suggested that cannabis could mitigate the effects of Alzheimer's for this reason.
At the same time, we know that THC interferes with memory, and it's still uncertain what kinds of long-term effects the drug could have on memory functioning. No one has been able to prove definitively that it does or does not erode memory strength over time. Obviously, smoking it could cause lung damage. And, like the legal intoxicant alcohol, cannabis can become addictive.
Should cannabis be illegal, while alcohol flows? Unfortunately that's not the kind of question that science can answer. Let's leave the moral questions to courts, policymakers and shamans. I'll be off to the side, smoking a joint, thinking about my acetylcholine system and the many uses of the hippocampus.
U.S. Food and Drug Administration issued new safety information about these cholesterol-lowering drugs that are prescribed to millions of Americans to lower the risk of heart disease. If you're among them, you should understand what the FDA's new guidance means for your health. "Before anyone gets too concerned, you should know that statins are so widely used because they have a long track record of safety and effectiveness," says Dr. Mark Taber, a cardiologist with SSM Heart Institute at St. Joseph Health Center. "All in all, statins have a very high benefit to risk ratio. The widespread use of the drugs, when indicated, probably accounts to a significant degree for the improvement in life expectancy in this country." The FDA called attention to the threat of liver damage as a rare side effect of statins and advised that regular liver enzyme testing is no longer considered useful in predicting or preventing liver injury. "Actually, in general they liberalized the follow up needed for liver function tests on patients taking statins, due to the very low incidence of true liver issues," Taber says. The main warnings related to a slightly higher incidence of developing diabetes while on statins, and a poorly substantiated claim that statins could result in cognitive impairment. Taber points out that cognitive problems, such as confusion or memory problems, were not documented in clinical studies, only by patient reports to the FDA website. "By stating these concerns, the FDA is raising awareness about the potential side effects of statins, but cardiologists already know that there are inherent risks, and we monitor patients appropriately to help ensure that side effects do not occur or are dealt with quickly," Taber notes. "If there is any evidence of a side effect that could be problematic, we can change the medication. But the fact remains that it's important to decrease risk of heart disease, and for many people statins are needed when diet and exercise alone don't result in acceptable cholesterol levels." Whenever a new prescription medication is started, you should look over the package insert to learn about potential side effects. Signs of liver damage, for instance, include fatigue, loss of appetite, right upper abdominal pain, dark urine and jaundice. Any of these symptoms should be reported to your doctor for evaluation. It is important to remember that you should not stop taking a medication without consulting your doctor first. Discontinuing use of a prescribed drug can be far more dangerous than the side effect you're worried about. "All the side effects listed by the FDA are rare, and the risk of heart attack is far more concerning," Taber says. "Some patients may need extra monitoring or may need to try more than one statin before we find the optimal choice, but in general statins are very well tolerated and don't cause problems for the people who take them." The advice above is universal when it comes to your health. Concerns should be discussed with your doctor, and decisions should always be made as part of a team approach to creating a healthy life.
John Holliday had been on a higher 40mg dose of cholesterol pills for only a few weeks when he started to lose his concentration. ‘I’d be watching TV and suddenly find myself unable to follow the plot of a drama,’ says John, 52, a telecoms project manager who lives in Southend-on-Sea, Essex, with his wife Jill, 51, and their two children Adam, 20, and Emma, 16. ‘I’d have to read the same page of a book over and over because I couldn’t take any information in. ‘I’d always been known for my amazing memory — I was great on trivia and had total recall of events that happened 20 years ago, but suddenly I couldn’t remember things and my brain felt fuzzy.’ Just like up to seven million other people in Britain, John had been prescribed a statin to lower his blood cholesterol levels. The drugs are credited by the British Heart Foundation as contributing towards the dramatic 50 per cent fall in deaths from heart attacks in the past ten years. But while there is consensus that statins are lifesavers for people who have previously had a heart attack, concern is growing over their debilitating side-effects. They include muscle weakness, depression, sleep disturbance, sexual dysfunction, muscle pain and damage, gastro-intestinal problems, headaches, joint pains and nausea. Now, official bodies here and in the U.S. have ordered that the drugs must carry warnings for cognitive problems, too. Worryingly, it’s claimed GPs are failing to warn patients of the effect statins can have on the mind — meaning they may mistake them for signs of ageing or Alzheimer’s. ‘When I went back to my doctor after six weeks for a blood test, I told him how dreadful I was feeling,’ says John. ‘But he just said all drugs had side-effects and didn’t mention reducing the dose.’ It's claimed GPs are failing to warn patients of the effect statins can have on the mind - meaning they may mistake them for signs of ageing or Alzheimer's Things came to a head when a friend showed John an electrical circuit he’d built for his car. ‘I’d worked with circuits since I was 16 but it made no sense,’ he says. So John insisted on seeing his doctor again and repeated his concerns about his rapidly declining memory. This time the GP told him he could start on another type of statin when he felt well enough, and so John stopped taking the drugs immediately. ‘It took a few months, but gradually my memory returned and I’ve got my concentration back. I can’t say for sure statins caused these problems, but it seems like too much of a coincidence.’ Earlier this year, the Food and Drug Administration (FDA) in the U.S. ordered statins must carry warnings that some users have reported cognitive problems including memory loss, forgetfulness and confusion. This followed a decision by the UK’s Medicines Healthcare Regulatory Agency (MHRA) to add memory problems to the list of possible statin side-effects in late 2009. The FDA said reports about the symptoms were from across all statin products and age groups. Those affected reported feeling fuzzy or unfocused in their thought process — though these were found to be rare and reversible. The FDA also warned, following U.S. research, that patients on statins had a small excess risk of developing Type 2 diabetes — but stressed that the benefits of taking a statin still outweigh this. The MHRA had 2,675 reports for adverse drug reactions connected with statins between 2007 and 2011. Officially, side-effects are rare —affecting only 1 per cent of people on the pills — but some doctors say they are under-reported. Dr Malcolm Kendrick, a GP and author of The Great Cholesterol Con, says he frequently sees patients suffering from mental confusion in his job in hospital intermediary care for the elderly. ‘Many of the patients I see will have been admitted to hospital after a fall or similar crisis,’ he says. ‘If they appear confused I’ll often advise taking them off statins to see if it has any effect — in my experience, about 10 to 15 per cent of people who appeared to have memory problems experienced an improvement in their memory symptoms after being taken off the drug. ‘I had one dramatic case where a lady was admitted to hospital on 40mg a day of simvastatin with such poor memory function her family asked me about power of attorney. 'I suggested taking her off statins and within a week her memory had returned to normal. She went home a fit and independent 83-year-old.’ Dr Kendrick says cholesterol is the main constituent of synapses (structures that allow signals to pass between brain cells and to create new memories) and is essential for brain function. ‘It is still not proven that statins have a significant effect on mortality — it has been calculated that a man who has had a heart attack who took a statin for five years would extend his life by only 14 days. 'Too many statins are being given to people at low risk. ‘Even in the highest risk group you need to treat 200 people a year with statins to delay just one death. 'One day the harm these drugs are doing is going to be obvious — the benefits are being over-hyped and the risks swept under the carpet.’ While Dr Kendrick’s controversial view is in the minority, one large review of 14 studies by the London School of Hygiene and Tropical Medicine, published by the highly respected Cochrane Library last year, concluded there was ‘little evidence’ cholesterol-lowering drugs protect people who are not at risk of heart disease. This review has been criticised by other doctors who say side-effects are rare and that there are still benefits even for people at lower risk who do not have established heart disease. These defenders of statins include Professor Colin Baigent of the Clinical Trial Service at Oxford University, who published research in 2010 showing statins reduced deaths from all causes by 10 per cent over five years. ‘There is relatively little evidence of cognitive impairment — what evidence there is all comes from observational studies. ‘People read about side-effects and then put two and two together and blame the statins for their muscle pain or other health problems — it’s just not reliable evidence. ‘If you look at the best-quality randomised controlled trial where patients don’t know if they are taking a statin or placebo, there is no evidence of memory problems. 'Even the FDA says the risks of cognitive problems are very small and go away when statins are discontinued. ‘We’re in danger of forgetting just how effective these drugs are.’ Dr Dermot Neely of the charity Heart UK, and lead consultant at the Lipid and Metabolic Clinic at the Royal Victoria Infirmary in Newcastle, agrees side-effects with statins are rare. ‘I’ve been dealing with patients on statins since 1987 and I can count on the fingers of one hand the number whose memory symptoms turned out to be caused by statins.’ However, he said he often saw patients who had not been told about side-effects. ‘It’s important GPs are clear about the drugs statins can interact with, such as certain antibiotics, as this can get overlooked. ‘If a patient notices an adverse effect after starting statins, they should discuss this with their GP —but not stop their drugs suddenly because this can be dangerous.’ Sonya Porter, 73, decided to stop taking statins after her memory problems became so bad that she walked away from a cashpoint leaving her money behind. ‘I was permanently fuzzy-headed and just couldn’t seem to concentrate,’ says Sonya, a retired PA from Woking, Surrey. Then I started to get scared I might have Alzheimer’s. After reading about memory problems associated with statins, I thought it was at least a possibility. I decided to come off the pills to see if it made any difference. ‘I didn’t ask my GP, I just did it — I’d rather die of a heart attack than Alzheimer’s disease. Within a month I felt normal again and didn’t have any problems with memory. ‘I’m terrified that I could have been misdiagnosed with Alzheimer’s.’ John Holliday is also reluctant to go back on statins. ‘I wouldn’t rule it out completely — my latest test showed my cholesterol levels have gone up,’ he says. ‘But on balance, I’d rather take my chances with heart disease than feel as confused as that again. It’s all very well living slightly longer — but it’s about quality of life, too.’
Between 2004 and 2007 there were 282 cocaine-related deaths
In the same period there were 376,000 users per year aged 25 or less
And there were 133,000 over 35s using every year during that time
Men are more than twice as likely to die from cocaine than females
Almost one in 10 Britons aged 15-64 have taken cocaine (and one in seven aged 15-34) - the highest in Europe
Spain next, with 8.3 per cent and Ireland fourth with 8.2 per cent
Usage between 15-34 increased by 50 per cent since 2003
Cannabis still more widely used than cocaine: 75.5million Europeans have smoked (one in four)
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A bit of the old timey wimey
