Stress can be physical,And then there’s the kind that’s in our heads — that OMG I’m so overwhelmed right now feeling. While psychological stress has some definite downsides (chronic freak-outs may increase our risk for cancer and other diseases), take a moment to exhale. In moderate amounts, stress can boost our focus, energy, and even our powers of intuition.
Still, in some cases, stress does more than light a productivity-boosting fire under our butts. Both emotional and physical stress activate our central nervous system, causing a “natural high,” says Concordia University neuroscientist and addiction specialist Jim Pfaus. “By activating our arousal and attention systems,” Pfaus says, “stressors can also wake up the neural circuitry underlying wanting and craving — just like drugs do.”
This may be why, experts believe, some of us come to like stress a little too much.
Type A and Type D personalities — or people prone to competitiveness, anxiety, and depression — may be most likely to get a high from stressful situations, says stress management specialist Debbie Mandel. Stress “addicts,” Mandel says, “may also be using endless to-do lists to avoid less-easy-to-itemize problems — feelings of inadequacy, family conflicts, or other unresolved personal issues.”
Some stress junkies have difficulty listening to others, concentrating, and even sleeping because they can’t put tomorrow’s agenda out of their minds, explains Mandel. Others tend to use exaggerated vocabulary — craaazy busy right now, workload’s insane!! And some begin to feel anxious at the mere thought of slowing down their schedule.
But psychologist and addiction researcher Stanton Peele cautions against labeling anyone a stress addict. “Only when that pursuit of stress has a significant negative impact on your life could it qualify as addiction,” he said, adding that many people are able to effectively manage — and in fact thrive under — high stress conditions. (Think: Olympic athletes or President Obama.)
Study: Stress Shrinks the Brain and Lowers Our Ability to Cope with Adversity
For budding stress “addicts” or for those who just, well, feel overwhelmed, here are some tips to dial down that anxiety:
Seek professional help if you’re verging on burnout. (Not only can hashing it out with a therapist take a load off your mind. Some studies suggest it also boosts physical fitness.)
Do something creative. Mandel recommends carving out a once-weekly time not to think about tomorrow’s agenda by painting, cooking, writing, dancing, or anything else that’ll take you off the clock temporarily.
Take it outside. Numerous studies show spending time in nature improves general well-being, lowers anxiety, stress and depression, and even boosts self-confidence. Especially for women. (As it turns out, most addiction recovery centers offer outdoor-immersion programs.)
Calm down quickly. If you really don’t have time for any of the above, these 40 tricks to chill take five minutes or less.
Some of us may seek out stress a bit more excessively than others and struggle to just relax. It takes skill to handle hectic agendas and long lists of responsibilities — without losing sleep or feeling frazzled. So try these tips and try not to freak out.
Worried that you or someone you know seeks out stress a little too much? Think stress addiction is a myth? Tell us about it in the comments section below.
Turns out, those glasses of wine would be a lot healthier if they were non-alcoholic, a new study shows. Spanish researchers led by Gemma Chiva-Blanch of the University of Barcelona found that non-alcoholic red wine reduced blood pressure in men at high risk for heart disease better than standard red wine or gin, according to the study published in the American Heart Association journal Circulation Research. Although the reduction in both systolic and diastolic blood pressure was modest, decreases of just 4 and 2 mm Hg have been associated with a 14 to 20 percent reduction in heart disease and stroke, the researchers pointed out. “The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension,” they concluded. Although there have been many studies on the impact of moderate drinking on health, the findings have been mixed, with some studies showing a benefit and others suggesting none. The new study found that 3 ounces of gin a day had no impact on blood pressure, while consumption of regular red wine led to a small, but not statistically significant, improvement. The new study suggests that if you’re going to have a drink, red wine would be the healthiest choice, said Dr. Kelly Anne Spratt, a heart disease prevention specialist and a clinical associate professor of medicine at the University of Pennsylvania. Still, Spratt said, “while there are those of us in cardiology who believe in the benefits of red wine, we want to be wary. We’re not going like gangbusters recommending people go out and start drinking. There are a lot of problems associated with drinking, like weight gain, cardiomyopathy, alcoholism, an increased breast cancer risk in women who consume two or more drinks a day.” Chiva-Blanch and her colleagues suspect that blood pressure improvements were due to the impact of polyphenols, a red wine component, on nitric oxide. The theory is that nitric oxide molecules help blood vessels relax, which allows better flow and more blood to reach the heart and other organs. For the new study, Chiva-Blanch and her colleagues followed 67 men with diabetes or three or more cardiovascular risk factors. During the study, the men were all required to consume the same foods along with one of three drinks: 10 ounces of red wine, 10 ounces of non-alcoholic red wine or 3 ounces of gin. During the 12 week study, the men tried each diet/beverage combination for four weeks at a time. The researchers determined that the standard red wine and its nonalcoholic counterpart contained equal amounts of polyphenols, an antioxidant which has been shown to decrease blood pressure. Men who drank regular red wine saw minor reductions in blood pressure – too small, in fact, to be statistically significant. Those who drank gin with their meals saw no change in blood pressure. But men who drank non-alcoholic red wine saw a blood pressure decrease of about 6 mm Hg in systolic and 2 mm Hg in diastolic blood pressure. Chiva-Blanch and her colleagues concluded that their findings show that the alcohol in red wine actually weakens its ability to lower blood pressure.
The convicted Colombian drug smuggler known as the “Godmother of Cocaine,” Griselda Blanco, 69, was gunned down by a motorcycle-riding assassin in Medellin, Colombian national police confirmed late Monday, according to the Miami Herald.
Blanco spent nearly 20 years in prison in the United States for drug trafficking and three murders before being deported to Colombia in 2004, the Herald reported.
Two armed riders pulled up to Blanco as she was leaving a butcher shop in her hometown, and one shot her twice in the head, the Herald reported, citing a report in El Colombiano newspaper.
Family members said Blanco had cut her ties to organized crime after returning to her country, the BBC reported. Police said they were investigating the motive.
Blanco was one of the first to engage in large-scale smuggling of cocaine into the United States from Colombia and set up many of the routes used by the Medellin cartel after she was sentenced in the United States in 1985, the BBC reported.
Investigators told the Herald that they estimate conservatively that Blanco was behind about 40 slayings. She was convicted in connection with three murders: Arranging the killing of two South Miami drug dealers who had not paid for a delivery, and ordering the assassination of a former enforcer for her organization, an operation that resulted in the death of the target’s 2-year-old son, the Herald reported.
Three of Blanco’s husbands were killed in violence related to drugs, the Herald reported, and one of her sons was named Michael Corleone, a reference to “The Godfather” movies.
Blanco is credited with originating motorcycle assassinations, the Herald reported.
“This is classic live-by-the-sword, die-by-the-sword,” filmmaker Billy Corben, who with Alfred Spellman made two “Cocaine Cowboys” documentaries, told the Herald. “Or in this case, live-by-the-motorcycle-assassin, die-by-the-motorcycle assassin.”
It was pretty much all the money Bozena Oracz had after a working life as an accountant: the equivalent of $15,000. She placed it in a fund investing in gold, with the hope of paying for her daughter's studies and getting treatment for a bad knee.
Those dreams were dashed when she discovered she had fallen victim to an elaborate fraud scheme that has left thousands of Poles, many of them elderly, facing financial ruin.
The so-called Amber Gold affair is one of the biggest financial scandals to hit Poland since the fall of communism in 1989. The extent of wrongdoing is still murky, but it seems to have some elements of a pyramid scheme, meaning the financial institutionused funds from new clients to pay off older clients rather than investing them.
Consumed with anger and desperation, 58-year-old Oracz traveled last week from a small town near Warsaw to a law firm in the capital to consider whether, after losing 50,000 zlotys, she should risk another 3,000 zlotys ($920; €730) on the fee to join a class-action lawsuit seeking to recover some of the losses.
"This was a lot of money to me — it was my savings," Oracz said, fighting back tears. Now retired and living on a small pension, she sees no way of building another nest egg. "My pension barely covers my needs," she said.
The affair has raised questions about the effectiveness of Poland's justice system and government because authorities failed to act against the scheme despite red flags from regulators and the criminal record of its young owner. Scrutiny has also focused on the prime minister due to business dealings his son had with those running the scheme. The scandal has even touched democracy icon Lech Walesa, who fears it could tarnish his good name.
Prosecutors say investors lost about 163 million zlotys ($50 million; €40 million), a number that has been mounting as more and more victims come forward. Any law suits could take care years to go through the courts, with no guarantee of their outcome.
"People are desperate," said Pawel Borowski, a lawyer preparing the class-action suit that Oracz is considering joining. "In most cases the clients lost life savings or sold family properties to make investments."
The financial institution, Amber Gold, promised guaranteed returns of 10 to 14 percent a year for what it claimed were investments in gold. Many of its clients were older Poles who grew up under communism and lacked the savvy to question how a financial firm could guarantee such a high return on a commodity whose value fluctuates on the international market. The promised returns compared well to the 3 to 5 percent interest offered by banks on savings accounts — earnings essentially wiped out by the country's 4 percent inflation rate.
"These were people with a low level of financial education," said Piotr Bujak, the chief economist for Poland at Nordea Markets. "They think it's still like in the old times, where everything was guaranteed by the state. They underestimated the risk."
Amber Gold launched in 2009, opening branches in city centers alongside respected banks, with white leather sofas and other sleek touches that conveyed sophistication and respectability. It bombarded Poles with convincing advertisements. Some early investors got out with their expected gains, adding to the fund's credibility.
The company, based in Gdansk, capitalized on gold's allure while playing on people's anxieties in unpredictable financial times. "We are dealing with a loss of confidence in the entire financial system and an urgent need for safe investments," one ad said. "The environment for gold is perfect."
Amber Gold drew in 50,000 investors over its three years of operation, though the company's founder, Marcin Plichta, said there were only about 7,000 at the time of liquidation.
Soon after Amber Gold began operations, the Polish Financial Supervision Authority put it on a "black list" of institutions that operate like banks without authorization. There are 17 other such black-listed institutions in operation, but the regulators lack the authority to shut them down. This has sparked a debate in the government and news media about whether courts should be more aggressive in intervening.
According to prosecutors, the company did use some of its money to invest in at least one legitimate business: It was the main investor in budget airline OLT Express. It was this investment that brought Amber Gold down — when the airline filed for bankruptcy, Amber Gold entered liquidation and its scheme of investments unraveled. Its bank accounts were blocked and it was unable to return the money of thousands of its customers.
Plichta was charged this month with six counts of criminal misconduct.
Prime Minister Donald Tusk's center-right government went into damage-control mode when it emerged that the leader's son, Michal Tusk, had done PR work for the airline. Tusk said he had warned his son against doing business with Plichta but that ultimately he son makes his own decisions.
Leszek Miller, the head of the opposition Democratic Left Alliance, asked how Tusk could warn his son against involvement in the airline but not warn the thousands of Poles who invested in the fund. Miller has called for a parliamentary inquiry into the scandal.
Public discontent is also centering on the justice system because Plichta, 28, has past convictions for fraud, and many Poles are asking why authorities — aware of his criminal record — didn't stop him sooner. Born Marcin Stefanski, he took his wife's last name to distance himself from his past crimes.
The country's top prosecutor, Andrzej Seremet, admitted Monday that prosecutors were negligent in failing to heed multiple warnings since 2009 about Amber Gold from the financial supervisory body. He announced personnel changes in the office he blamed for mistakes.
The affair also has an unlikely connection to the Solidarity leader and former president, Lech Walesa, because an Oscar-winning director, Andrzej Wajda, was relying on money from Amber Gold to produce a film about Walesa's struggle in the 1980s.
Walesa came out publicly to make clear he is not involved in any way, saying he doesn't want his name "dirtied."
Many of the unlucky investors are not only furious but wracked by shame and guilt.
Engineer Andrzej Malinowski, 61, put three months of salary — 25,000 zlotys ($7,660; €6,100) — into Amber Gold. He made the investment without consulting with his wife, sensing that there was some risk and that she would not have agreed.
Now he is so shaken and embarrassed that he doesn't want to talk about it, leaving his wife, Danuta Malinowska, to help unravel the mess.
"He saw that gold was going higher and higher so he believed that maybe it would be a good deal," Malinowska said. "Now he has so much guilt that I am trying to help — contacting the lawyer, filling in the forms, writing to the prosecutors. But the justice system is very ineffective. I don't believe we will be getting any of this money back."
This undated image taken from the Mexican Attorney General's Office rewards program website on Aug. 23, 2012, shows the alleged leader of Zetas drug cartel, Miguel Angel Trevino Morales, alias âZ-40.â (AP Photo/Mexican Attorney General's Office website)
Mexico's Violent Zetas Cartel Sees New Leader Miguel Angel Trevino Morales A split in the leadership of Mexico's violent Zetas cartel has led to the rise of Miguel Angel Trevino Morales, a man so feared that one rival has called for a grand alliance to confront a gang chief blamed for a new round of bloodshed in the country's once relatively tranquil central states.
Trevino, a former cartel enforcer who apparently has seized leadership of the gang from Zetas founder Heriberto Lazcano Lazcano, is described by lawmen and competing drug capos as a brutal assassin who favors getting rid of foes by stuffing them into oil drums, dousing them with gasoline and setting them on fire, a practice known as a "guiso," or "cook-out".
Law enforcement officials confirm that Trevino appears to have taken effective control of the Zetas, the hemisphere's most violent criminal organization, which has been blamed for a large share of the tens of thousands of deaths in Mexico's war on drugs, though other gangs too have repeatedly committed mass slayings.
"There was a lot of talk that he was pushing really hard on Lazcano Lazcano and was basically taking over the Zetas, because he had the personality, he was the guy who was out there basically fighting in the streets with the troops," said Jere Miles, a Zetas expert and U.S. Immigration and Customs Enforcement special agent who was posted in Mexico until last year.
"Lazcano Lazcano, at the beginning he was kind of happy just to sit back and let Trevino do this, but I don't think he understood how that works in the criminal underworld," Miles said. "When you allow someone to take that much power, and get out in front like that, pretty soon the people start paying loyalty to him and they quit paying to Lazcano."
The rise has so alarmed at least one gang chieftain that he has called for gangs, drug cartels, civic groups and even the government to form a united front to fight Trevino Morales, known as "Z-40," whom he blamed for most of Mexico's violence.
"Let's unite and form a common front against the Zetas, and particularly against Z-40, Miguel Angel Trevino Morales, because this person with his unbridled ambition has caused so much terror and confusion in our country," said a man identified as Servando Gomez, leader of the Knights Templar cartel, in a viedo posted Tuesday on the internet.
A Mexican law enforcement official who wasn't authorized to speak on the record said the video appeared to be genuine,
"He is the main cause of everything that is happening in Mexico, the robberies, kidnappings, extortion," Gomez is heard saying on the tape. "We are inviting all the groups ... everyone to form a common front to attack Z-40 and put an end to him."
Trevino Morales has a fearsome reputation. "If you get called to a meeting with him, you're not going to come out of that meeting," said a U.S. law-enforcement official in Mexico City, who spoke on condition of anonymity because of the sensitivity of the topic.
In two years since Zetas split with their former allies in the Gulf cartel — a split in which Trevino reported played a central role — the gang has become one of Mexico's two main cartels, and is battling the rival Sinaloa cartel.
Now the Zetas' internal disputes have added to the violence of the conflict between gangs. Internal feuds spilled out into pitched battles in the normally quiet north-central state of San Luis Potosi in mid-August, when police found a van stuffed with 14 executed bodies.
San Luis Potosi state Attorney General Miguel Angel Garcia Covarrubias told local media that a 15th man who apparently survived the massacre told investigators that both the killers and the victims were Zetas. "It was a rivalry with the same organized crime group," Garcia Covarrubias said.
The leadership dispute also may have opened the door to lesser regional figures in the Zetas gang to step forward and rebel, analysts and officials said.
Analysts say that a local Zetas leader in the neighboring state of Zacatecas, Ivan Velazquez Caballero, "The Taliban," was apparently trying to challenge Trevino Morales' leadership grab, and that the 14 bullet-ridden bodies left in the van were The Taliban's men, left there as a visible warning by Trevino Morales' underlings.
The Taliban's territory, Zacatecas, appears to have been a hot spot in Trevino's dispute with Lazcano. It was in Zacatecas that a professionally printed banner was hung in a city park, accusing Lazcano of betraying fellow Zetas and turning them in to the police.
Trevino began his career as a teenage gofer for the Los Tejas gang, which controlled most crime in his hometown of Nuevo Laredo, across the border from the city of Laredo, Texas, officials say.
Around 2005, Trevino Morales was promoted to boss of the Nuevo Laredo territory, or "plaza" and given responsibility for fighting off the Sinaloa cartel's attempt to seize control of its drug-smuggling routes. He orchestrated a series of killings on the U.S. side of the border, several by a group of young U.S. citizens who gunned down their victims on the streets of the American city. American officials believe the hit men also carried out an unknown number of killings on the Mexican side of the border, the U.S. official said.
Trevino Morales is on Mexico's most-wanted list, with a reward of 30 million pesos ($2.28 million) offered for information leading to his capture.
Raul Benitez, a security expert at Mexico's National Autonomous University, said that the Zetas are inherently an unstable cartel with an already huge capacity for violence, and the possibility of more if they begin fighting internal disputes. "I think the Zetas are having problems, and there is no central command," he said.
The Zetas have been steadily expanding their influence and reaching into Central America in recent years, constructing a route for trafficking drugs that offloads Colombian cocaine in Honduras, ships it overland along Mexico's Gulf Coast and runs into over the border through Trevino Morales' old stomping grounds.
Samuel Logan, managing director of the security analysis firm Southern Pulse, notes that "personality-wise they (Trevino Morales and Lazcano) couldn't be more different," and believes the two may want to take the cartel in different directions. The stakes in who wins the dispute could be large for Mexico; Lazcano is believed to be more steady, more of a survivor who might have an interest in preserving the cartel as a stable organization.
"Lazcano may be someone who would take the Zetas in a direction where they'd become less of a thorn in the side for the new political administration," Logan said in reference to Enrique Pena Nieto, who is expected to take office as president on Dec. 1. "In contrast, Trevino is someone who wants to fight the fight."
Referring to Ignacio "Nacho" Coronel, a member of the rival Sinaloa Cartel who died in a shootout with soldiers in July 2010, Logan noted, "Trevino is someone who is going to want to go out, like Nacho Coronel went out, with his guns blazing."
Laurence Kilby, 40, of Cheltenham, who built and raced cars, was arrested after police seized cocaine with a street value of £1m.
A "privileged" racing driver has been jailed with 11 other drug smugglers. Crown Court heard he was head of a gang moving drugs from Eastern Europe along the M4 corridor to London, western England and south Wales.
Kilby was heavily in debt and turned to crime to maintain his lifestyle of fast cars and high living.
Raids on properties
Kilby was jailed in June but his conviction, and those of the rest of the gang, can now be reported following the conclusion of another trial.
In an undercover operation between Gloucestershire and Avon and Somerset Police, officers seized 3kg of cocaine as it was being ferried between London and Cheltenham in October 2010.
Another 1kg of the drug was intercepted in Cheltenham in February 2011 and 2.5kg was discovered in raids on properties in Cheltenham, Staverton, Bristol and London in July 2011.
The gang of 12 drug dealers from Gloucestershire, Bristol and London received sentences of between 18 years and four years seven months.
It can now be reported Kilby, who was jailed in June, and Vladan Vujovic, 43, of Grange Road, London were found guilty of conspiracy to supply Class A drugs. Both were jailed for 18 years.
Kilby built and raced cars with the company he owned, Ajec Racing
Richard Jones, 42, of Bradley Stoke, Bristol, was sentenced to 15 years for the same offence, and Mark Poole, 47, from Portishead, was sentenced to nine years seven months after pleading guilty to conspiracy to supply Class A drugs.
Police said Kilby sourced the drug in London from an East European criminal gang, which included Vujovic.
Vujovic ran a baggage handling company at Heathrow Airport and was said to receive the cocaine before it was distributed around the South West and Wales.
Kilby is the former husband of Flora Vestey, daughter of Lord Vestey, and was owner of motor racing firm Ajec Racing which was based in Staverton.
He was heavily in debt and turned to crime to maintain his lifestyle of fast cars and high living.
'Well-connected socialite'
In a separate charge, Kilby also pleaded guilty to stealing money from the charity Help for Heroes and was sentenced to 10 months, to run concurrently with his 18-year sentence.
He organised a charity race day at Gloucestershire Airport in July 2010, but failed to pass on between £3,500 and £4,000 in proceeds to the charity Help for Heroes.
Det Insp Steve Bean, from Gloucestershire Police, said Kilby was the main man.
"He portrayed himself as a well-connected socialite and businessman, whilst indulging his ambition as a minor league racing driver.
Police seized 6.5kg of drugs during the operation
"Despite a privileged background, the reality was that his lifestyle was funded by the ill-gotten gains of drug dealing.
"He continually lied and blamed others in an attempt to distance himself from the conspiracy.
"He displayed an air of arrogance and thought he could get away with it because he didn't get his hands dirty."
The majority of the gang were jailed in June, but reporting restrictions meant it could not be reported until now, after the sentencing of the remaining gang members.
Others members of the gang to be sentenced were:
David Chapman, 29, from Bourton-on-the-Water, Gloucestershire, pleaded guilty to possession with intent to supply and was sentenced to nine years.
William Garnier, 31, from Cheltenham, pleaded guilty to supplying Class A drugs and was sentenced six years and eight months.
Garry Burrell, 46, from Easton, Bristol, and John Tomlin, 28, from Newtown, Gloucestershire both pleaded guilty to possession of cocaine and were sentenced to six years and six months and four years and six months respectively.
Timothy Taylor, 40, from Bristol was found guilty of supplying Class A drugs and was sentenced to four years and seven months.
Brian Barrett, 48, from Keynsham was found guilty of conspiracy to supply Class A drugs and was sentenced to 10 years.
Scott Everest, 39, from Clevedon was found guilty of conspiracy to supply Class A drugs and was jailed for seven years.
Jonathan Tanner, 45, from Warminster was sentenced to 18 months for possession with intent to supply of cannabis, but was cleared of conspiracy to supply Class A drugs.
Darren Weetch, 38, from Bristol, pleaded guilty to possession of cocaine with intent to supply. He was sentenced to 16 months.
Officers also worked with Thames Valley Police and the Metropolitan Police during the operation.
Civilians occasionally find themselves in harm's way when officers use deadly force, though usually only a handful of times annually. When that happens, a rigid process of investigation is set in motion — and the police department can reasonably expect a lawsuit. The latest episode came when police say a man disgruntled over losing his job a year ago shot a former colleague to death and pointed his weapon at two police officers in the shadow of a major tourist attraction. He apparently wasn't able to fire before police killed him, one firing off seven rounds and the other nine. Bystanders suffered graze wounds, and some were struck by concrete gouged from buildings by the bullets, authorities said. At least one person said he was actually hit by a bullet. Robert Asika, a 23-year-old tour guide who was hit in the right arm, said he was "100 percent positive" he was shot by a police officer. A witness told police that laid-off clothing designer Jeffrey Johnson fired at officers, but ballistics evidence so far contradicts that, authorities said.
A Trail of Ink: Tracking a Rare Tattoo-Related Infection
An uncommon skin infection led to a doctor's investigation into tainted tattoo ink. (Monroe County Health Department)
The reddish-purple rash, seemingly woven into the tattoo on a 20-year-old New Yorker's forearm, was strange enough to have doctors scratching their heads.
This trail began when the man received a tattoo in Rochester, N.Y. in October 2011. A short while later, he noticed the raised, bumpy rash. He called his primary care physician.
Doctors initially treated the man's arm with topical steroids, thinking that the rash was allergic-contact dermatitis. But that only made the problem worse.
By the time dermatologist Dr. Mark Goldgeier saw the patient, it was clear that this was no simple allergy.
He performed a skin biopsy so he could take a closer look at the rash under a microscope. What he saw was startling: the sample was riddled with a wormlike bacterium related to tuberculosis.
"I explained [to the patient] that he had TB, and he had a look of horror on his face," Goldgeier said.
For the patient, the finding meant a trip to an infectious disease specialist to start up to a full year of treatment.
Goldgeier, meanwhile, called the Monroe County Health Department.
"As soon as biopsy came back," he said, "I knew something in the process of tattooing was involved -- the ink, the water used for dilution, the syringes, the dressings."
And so began a nationwide medical mystery.
An article published Wednesday in the New England Journal of Medicine describes how this one dermatologist helped connect the dots in an outbreak of tattoo-related atypical skin infections.
Dr. Byron Kennedy, public health specialist at Monroe County Department of Public Health, took over the case from Goldgeier. Kennedy first confirmed the results by repeating a skin biopsy on the patient. Once again, tendrils of mycobacterium chelonae, a type of tuberculosis-related skin bacteria, showed up in the sample.
Mycobacterium chelonae is a rapidly growing bug found in soil, dust, water, animals, hospitals, and contaminated pharmaceuticals. This family of bacteria does not commonly affect healthy individuals, but in patients with suppressed immune systems -- like those with HIV or on chemotherapy -- these bacteria can cause serious disease, often resulting in death.
The finding sent Kennedy and his associates to the tattoo parlor where the patient had been inked. Everything in the clinic was sterile, which made it unlikely that the infection had arisen there. But the tattoo artist, they learned, had been using a new gray premixed ink purchased in Arizona in April 2011; he used the ink between May and December 2011.
The ingredients of the ink -- pigment, witch hazel, glycerin, and distilled water -- seemed innocuous enough. But further examination revealed that the distilled water in the pigment was the likely culprit of the contamination.
The finding raised a number of questions -- not the least of which was how the bottles of premixed ink passed U.S. Food and Drug Administration regulations.
The U.S. Centers for Disease Control and Prevention acknowledged this gap in regulations Wednesday in its Morbidity and Mortality Weekly report.
"Under the Federal Food, Drug, and Cosmetic Act, tattoo inks are considered to be cosmetics, and the pigments used in the inks are color additives requiring premarket approval," the report says.
Twenty-five people were killed and 43 others hurt in a prison battle in Venezuela as two armed gangs vied for control of a penitentiary near Caracas, authorities said on Monday.
The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.
They have devised a vaccine that floods the body with an antibody to assault nicotine entering the body.
A study in mice, published in Science Translational Medicine, showed levels of the chemical in the brain were reduced by 85% after vaccination.
Years of research are still needed before it could be tested on people.
However, lead researcher Prof Ronald Crystal is convinced there will be benefits.
"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect."
New approach
Other "smoking vaccines" have been developed that train the immune system to produce antibodies that bind to nicotine - it is the same method used to vaccinate against diseases. The challenge has been to produce enough antibodies to stop the drug entering the brain and delivering its pleasurable hit.
Scientists at Weill Cornell Medical College have used a completely different approach, a gene-therapy vaccine, which they say is more promising.
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“Start Quote
If they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit”
Prof Ronald CrystalWeill Cornell Medical College
A genetically modified virus containing the instructions for making nicotine antibodies is used to infect the liver. This turns the organ into a factory producing the antibodies.
The research team compared the amount of nicotine in the brains of normal mice with those that had been immunised. After being injected with nicotine, the vaccinated mice had nicotine levels 85% lower.
It is not known if this could be repeated in humans or if this level of reduction would be enough to help people quit.
Prof Crystal said that if such a vaccine could be developed then people "will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit".
He added: "We are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches."
'Impressive and intriguing'
There are also issues around the safety of gene therapy in humans that will need to be answered.
Professor of genetics at the University of Kent, Darren Griffin, said the findings were "impressive and intriguing with great potential" but cautioned there were still many issues which needed addressing.
He said the main issue "is whether the observed biochemical effects in lab mice genuinely translate to a reduced addiction in humans given that such addictions can be both physical and psychological".
Dr Simon Waddington, from University College London, said: "The technology underpinning gene therapy is improving all the time and it is encouraging to see these preliminary results that indicate it could be used to address nicotine addiction, which is damaging to the nation's health and a drain on the health service economy."
If such a vaccine was developed it could also raise ethical questions about vaccinating people, possibly in childhood, before they even started smoking.
Coca-Cola and Pepsi contain minute traces of alcohol, scientific research published in France has revealed. The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons. According to tests carried out by the Paris-based National Institute of Consumption (INC) more than half of leading colas contain the traces of alcohol. Can't beat the real thing: The revelation will cause concern among those who chose the carbonated soft drink for religious, health or safety reasons These include the brand leaders Coca-Cola and Pepsi Cola, while it is mainly only cheap supermarket versions of the drink which are alcohol-free. ‘60 Million Consumers’, the French magazine, publishes the results of the tests in its latest issue. They suggest that the alcohol levels are as low as 10mg in every litre, and this works out at around 0.001 per cent alcohol.
After the recent stream of disturbing news reports of people eating others' flesh, Hornaday Manufacturing has released bullets that promise to ‘make dead permanent.’
The ammunition, branded as Zombie Max offers Proven Z-Max bullets, is live ammunition, but is actually only intended for use on targets – not people.
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The Walking Dead: Hornady Manufacturing has started selling Zombie bullets, 'just in case'; it is live ammunition
Attacks: Carl Jacquneaux, left, who was arrested for allegedly biting another man's face and Brandon De Leon, right, who allegedly tried to bite two policemen while threatening to eat them
Hornaday spokesman Everett Deger told WWJ Newsradio 950 that the company’s president has a love of zombie culture – including popular shows like the Walking Dead – and was inspired to make the bullets in honour of the cultural phenomenon.
ON CLOUD NINE: BATH SALTS BY ANOTHER NAME... WITH STRONG COMPULSIONS TO REDOSE
The 'bath salts' sold under the name Cloud Nine are likely to be stimulant drugs such MPDV or ephedrine.
'Bath salts' does not refer to a single chemical, but instead to a range of synthetic drugs that can be sold legally in the U.S. as long as they are not marked for human consumption – hence the misleading name.
Drugs such as MPDV are highly potent stimulants, similar to some amphetamines, and in MPDV's case particularly, cause a strong compulsion to 'redose' with more of the drug.
In high doses, such drugs can cause violent and unpredictable behaviour, and terrifying hallucinations – and the compulsion to take more of the drug continues, even once the 'high' has begun to make the user feel bad.
Various different compounds use the name 'Cloud Nine', and it's still not confirmed which exact chemical was in the drug reported to have caused these attacks, but some reports have pointed the finger at MPDV.
The chemical is already illegal in Florida – although other 'bath salts' remain perfectly legal in the state.
‘We decided just to have some fun with a marketing plan that would allow us to create some ammunition designed for that…fictional world,’ he told the radio station.
Mr Deger noted that the bullets are some of the ammunition company’s most popular products.
The news comes as two more cannibal attacks have been reported in the US as police warn of a dangerous new mind-altering drug called Cloud Nine.
Last week Rudy Eugene - who is believed to have taken the over-the-counter ecstasy-like drug - growled at officers as he chewed off most of a homeless man's face before being shot dead by Miami police.
Since then two further incidents have been linked to the substance, which is part of a new line of 'bath salts'.
More...
Revealed: Miami cannibal's girlfriend shows herself in public for the first time and claims her beau was carrying a BIBLE before the attack
Caught on camera: The moment woman driver rams into pedestrian and travels for hundreds of yards with him clinging on 'because of her hormones'
Revealed: The videos 'Canadian cannibal' sent to his 'fans' while on the run from police - and one of them contains infamous song from American Psycho
The second occurred on Saturday when a snarling homeless man, identified as Brandon De Leon, threatened to eat two officers, echoing the Miami attack.
A third incident took place in Louisiana where Carl Jacquneaux, 43, bit off a chunk of his victim's face. Miami police have issued a warning about Cloud Nine and told their officers to exercise extreme caution when dealing with homeless men who appear to be acting unusually.
Police investigating the case of Rudy Eugene, who ate the face off a homeless man, say as well as being naked, he was carrying a bible.
Some pages had been ripped out of the book and were found close by, according to CBS Miami. A preliminary toxicology examination has also found that the 31-year-old had been smoked cannabis shortly before the incident.
They were forced to fit 21-year-old De Leon with a Hannibal Lecter-style mask after he was arrested for disturbing the peace in North Miami Beach. When put in a police cruiser De Leon slammed his head against the plexiglass divider and shouted at officers, 'I'm going to eat you', NBC Miami reported.
He then growled, gnashed his teeth and tried to bite the hand of an officer attempting to treat his head wounds.
'Brandon growled and opened and closed his jaw, slamming his teeth like an animal would,' the report said. Miami police said they believe he was on a cocktail of drugs, including Cloud Nine.
In a second case Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.
Victim: Todd Credeur, though in shock, managed to spray his attacker in the face with wasp spray to stop him from eating any more of his face
Scene: Todd Creneur was attacked while working on the yard outside his home in Scott, Louisiana
KATC reported that Mr Credeur was working in his front yard when he was attacked.
Scott Assistant Police Chief Kert Thomas said: 'During the attack, the suspect bit a chunk of the victim's face off.'
Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.
Jacquneaux then allegedly left the home and went to another man's home where he held him at knife point and stole a hand gun. This is where police found him and arrested him.
A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.
Eugene ate the face of homeless man Ronald Poppo in Miami last week and a police memo to officers has highlighted the dangers surrounding the drug's use.
It warned the De Leon case 'bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man's face'.
'Please be careful when dealing with the homeless population during your patrols.'
Police have suggested Eugene was under the influence of the synthetic stimulant usually sold in drug paraphanelia shops.
Cloud Nine is 'addictive and dangerous', the memo said, part of a 'disturbing trend in which new drugs are sold in the guise of household products'.
The drug, which is also as Ivory Wave in the U.S., comes in harmless-looking packets, police said, adding that it is illegal in Britain and Australia.
Crazed attack: Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene (left) when he savagely attacked 65-year-old Ronald Poppo (right)
The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour.
The series of shocking incidents began on May 26 when a naked Eugene encountered his victim, 65-year-old Ronald Poppo, who was sleeping in the shade on elevated train tracks.
In surveillance footage from the nearby Miami Herald building, Eugene was seen struggling with the naked homeless man, throwing him to the ground and then tearing into his face with his teeth as cars and bicycles sped by.
About 18 minutes into the attack, an officer appeared on the scene and yelled at Eugene to stop, but the 31-year-old just growled at him and continued chewing Poppo’s face.
The officer then opened fire on Eugene, shooting him to death.
Enlarge
Horrific attack: The spot on MacArthur Causeway when a man was killed after chewing the face off a stranger
Disfigured: Poppo, here on a stretcher, miraculously survived the attack, but was left without a nose, mouth or eyes
Poppo remains in critical condition at Jackson Memorial Hospital with his nose, mouth and eyes torn off. He faces months of treatment to rebuild his features and psychological care.
Controversially this week the scene of the attack on Poppo has been Miami added to sites visited by a tourist tour's itinerary.
The famous Miami Mystery & Mayhem: Crime Tour tour led by Miami-Dade College professor Dr Paul George will stop on the road that connects downtown Miami to popular South Beach.
Dr Paul told the South Florida Business Journal: 'Horrible as it was, it is part of our history. Currently, our tour takes us over the causeway right past the site, so this fits well.'
In a completely separate case not involving the drug, Canadian Luka Rocco Magnotta has been sent back to his country from Germany after an international manhunt.
He is alleged to have killed his partner, Jun Lin, before eating parts of his body then chopping it to pieces that were then posted to different authorities. Mr Lun's head has not yet been found.
'ZOMBIE APOCALYPSE': RECENT CANNIBAL ATTACKS ACROSS AMERICA
Since Rudy Eugene attacked and ate the face of homeless man Ronald Poppo on May 26 in Miami, Florida, while allegedly high on 'bath salts' there has been a spate of similar attacks.
The 'Miami Cannibal' case shocked the nation after police had to shoot dead Eugene when he refused to stop eating his victim's face off. Poppo is now recovering in hospital with horrific injuries.
Brandon DeLeon, 21, was high on drugs and drunk on Four Loko on June 2 when he tried to bite off a police officer’s hand after he was arrested for disturbing customers in a Miami fast food restaurant.
The homeless man repeatedly banged his head against the patrol car’s Plexiglas and yelled, ‘I’m going to eat you.’
At the police station, De Leon tried to bite the officer who was taking his blood pressure and tending to his self-inflicted wounds. The police report noted that he 'growled and opened and closed his jaw slamming his teeth like an animal would.'
Carl Jacquneaux, 43, is accused of attacking Todd Credeur at his home in Scott, Louisiana, over the weekend after he became upset following a domestic issue.
Mr Credeur reportedly managed to spray Jacquneaux in the face with wasp spray to stop him from eating any more of his face.
A friend of the victim said she believes Jacquneaux was under the influence of Cloud Nine, which is the same drug which is believed to have been taken by the 'Miami Cannibal' Rudy Eugene.
Alex Kinyua, 21, a college student, used a knife to carve up Kujoe Bonsafo Agyei-Kodie, 37, before eating his heart out and parts of his brain.
He then took to his social networking site to boast about it to his friends saying: 'Are you strong enough to endure ritual HBCU mass human sacrifices around the country and still be able to function as human beings?'
He referred to the tragic shootings at Virginia Tech and 'other past university killings around the country' and warned 'ethnic cleansing is the policy, strategy and tactics that will affect you, directly or indirectly in the coming months.'
Narcotic Cloud Nine was blamed for the attack when Rudy Eugene ate 75% of homeless man Ronald Poppo’s face in Miami last month.
Horrific images surfaced of the attack that only ended once police shot and killed 31-year-old Eugene.
Mr Poppo is still recovering from his injuries in hospital.
Police are now warning people to stay away from Cloud Nine – also known as ‘bath salts’ - after two similar attacks were reported.
The most recent prompted an internal memo to police warning officers the case “bears resemblance to an incident that occurred in the city of Miami last week, when a male ate another man’s face”.
The memo called the synthetic drug “addictive and dangerous” and said it was part of a “disturbing trend in which new drugs are sold in the guise of household products”.
It added: “Please be careful when dealing with the homeless population during your patrols.”
Rudy Eugene, 31: Ate 75% of a man's face in Miami before being shot dead
AP
Brandon De Leon, 21: Tried to bite two police officers after he was arrested in North Miami BeachCarl Jacquneaux, 43: Bit a man's face in Scott, Louisiania. Wasp spray was used to end the attackAlex Kinyua, 21: Accused of eating the heart and brain of friend in Maryland
Splash
Horror: Film cannibal Hannibal Lecter
Channel 5
During the latest attack homeless Brendon De Leon threatened to eat two Miami police officers and had to be fitted with a Hannibal Lecter-style mask to prevent him carrying his threats out.
He had been arrested for disturbing the peace in North Miami Beach while high on drugs and put in a police cruiser when he slammed his head against the plexiglass divider and shouted: “I’m going to eat you” to officers before growling and baring his teeth.
Miami police said they believe he was on a cocktail of drugs including Cloud Nine.
In another case, Carl Jacquneaux, 43, was accused of attacking Todd Credeur in his front garden in Scott, Louisiana, over the weekend after being upset over a domestic issue while under the influence of what is said to be bath salts.
Jacquneaux bit Mr Credeur before being sprayed in the face with wasp spray.
Scott Assistant Police Chief Kert Thomas said: “During the attack, the suspect bit a chunk of the victim’s face off.”
Jacquneaux was then said to have left the property and gone to another man’s home where he held him at knife-point and stole a handgun before being apprehended by police.
The drug, which is also known as Ivory Wave, was blamed for several deaths in Britain during 2010 before being banned. It is also illegal in Australia.
The potentially addictive drug stimulates the central nervous system and symptoms include heart palpitations, nausea, hallucinations, paranoia and erratic behaviour and is often sold in plain packaging with the contents purporting to be harmless.
Scotland Yard has urged Portuguese authorities to reopen the search for Madeleine McCann as detectives said there are 195 potential leads to finding her alive. The detective leading the Metropolitan Police review said the case can still be solved before officers released a picture of what she might now look like as a nine-year-old. Detective Chief Inspector Andy Redwood said he believes her disappearance was a stranger abduction, as he said there are 195 "investigative opportunities". Police refused to say what evidence they had uncovered to suggest Madeleine is alive. Mr Redwood confirmed that his team of more than 30 officers involved in the case had been out to Portugal seven times, including a visit to the family's holiday flat in Praia da Luz. It will be five years ago next week since the three-year-old went missing as her parents, Kate and Gerry McCann, dined with friends nearby. A spokesman for the McCanns said the family was pleased with the image. Mr Redwood said his 37 officers had dealt with 40,000 pieces of information but the "primacy still sits in Portugal" in the attempt to find her. Commander Simon Foy said: "Most significantly, the message we want to bring to you is that, on the evidence, there is a possibility that she is alive and we desperately need your help today to appeal directly to the public for information to support our investigation." Mr Redwood said "evidence that she is alive stems from the forensic view of the timeline" that there was the opportunity for her to be taken. Investigations show "there do appear to be gaps", he added. Detectives in Portugal are also understood to want the case reopened but must gain judicial approval via the courts.
Companies that do not do enough to keep their websites secure are to be named and shamed to help improve security. The list of good and bad sites will be published regularly by the non-profit Trustworthy Internet Movement (TIM). A survey carried out to launch the group found that more than 52% of sites tested were using versions of security protocols known to be compromised. The group will test websites to see how well they have implemented basic security software. Security fundamentals The group has been set up by security experts and entrepreneurs frustrated by the slow pace of improvements in online safety. "We want to stimulate some initiatives and get something done," said TIM's founder Philippe Courtot, serial entrepreneur and chief executive of security firm Qualys. He has bankrolled the group with his own money. TIM has initially focused on a widely used technology known as the Secure Sockets Layer (SSL). Experts recruited to help with the initiative include SSL's inventor Dr Taher Elgamal; "white hat" hacker Moxie Marlinspike who has written extensively about attacking the protocol; and Michael Barrett, chief security officer at Paypal. Continue reading the main story “ Start Quote Everyone is now going to be able to see who has a good grade and who has a bad grade” Philippe Courtot Many websites use SSL to encrypt communications between them and their users. It is used to protect credit card numbers and other valuable data as it travels across the web. "SSL is one of the fundamental parts of the internet," said Mr Courtot. "It's what makes it trustworthy and right now it's not as secure as you think." Compromised certificates TIM plans a two-pronged attack on SSL. The first part would be to run automated tools against websites to test how well they had implemented SSL, said Mr Courtot. "We'll be making it public," he added. "Everyone is now going to be able to see who has a good grade and who has a bad grade." Early tests suggest that about 52% of sites checked ran a version of SSL known to be compromised. Companies who have done a bad job will be encouraged to improve and upgrade their implementations so it gets safer to use those sites. The second part of the initiative concerns the running of the bodies, known as certificate authorities, which guarantee that a website is what it claims to be. TIM said it would work with governments, industry bodies and companies to check that CAs are well run and had not been compromised. "It's a much more complex problem," said Mr Courtot. In 2011, two certificate authorities, DigiNotar and GlobalSign were found to have been compromised. In some cases this meant attackers eavesdropped on what should have been a secure communications channel. Steve Durbin, global vice president of the Information Security Forum which represents security specialists working in large corporations, said many of its members took responsibility for making sure sites were secure. "You cannot just say 'buyer beware'," he said. "That's not good enough anymore. They have a real a duty of care." He said corporations were also increasingly conscious of their reputation for providing safe and secure services to customers. Data breaches, hack attacks and poor security were all likely to hit share prices and could mean they lose customers, he noted.
Commonly prescribed anti-depressants appear to be doing patients more harm than good, say researchers who have published a paper examining the impact of the medications on the entire body. See Also: Health & Medicine Pharmacology Birth Defects Mental Health Research Mind & Brain Depression Disorders and Syndromes Psychiatry Reference COX-2 inhibitor Psychoactive drug Seasonal affective disorder Anti-obesity drug "We need to be much more cautious about the widespread use of these drugs," says Paul Andrews, an evolutionary biologist at McMaster University and lead author of the article, published recently in the online journal Frontiers in Psychology. "It's important because millions of people are prescribed anti-depressants each year, and the conventional wisdom about these drugs is that they're safe and effective." Andrews and his colleagues examined previous patient studies into the effects of anti-depressants and determined that the benefits of most anti-depressants, even taken at their best, compare poorly to the risks, which include premature death in elderly patients. Anti-depressants are designed to relieve the symptoms of depression by increasing the levels of serotonin in the brain, where it regulates mood. The vast majority of serotonin that the body produces, though, is used for other purposes, including digestion, forming blood clots at wound sites, reproduction and development. What the researchers found is that anti-depressants have negative health effects on all processes normally regulated by serotonin. The findings include these elevated risks: developmental problems in infants problems with sexual stimulation and function and sperm development in adults digestive problems such as diarrhea, constipation, indigestion and bloating abnormal bleeding and stroke in the elderly The authors reviewed three recent studies showing that elderly anti-depressant users are more likely to die than non-users, even after taking other important variables into account. The higher death rates indicate that the overall effect of these drugs on the body is more harmful than beneficial. "Serotonin is an ancient chemical. It's intimately regulating many different processes, and when you interfere with these things you can expect, from an evolutionary perspective, that it's going to cause some harm," Andrews says. Millions of people are prescribed anti-depressants every year, and while the conclusions may seem surprising, Andrews says much of the evidence has long been apparent and available. "The thing that's been missing in the debates about anti-depressants is an overall assessment of all these negative effects relative to their potential beneficial effects," he says. "Most of this evidence has been out there for years and nobody has been looking at this basic issue." In previous research, Andrews and his colleagues had questioned the effectiveness of anti-depressants even for their prescribed function, finding that patients were more likely to suffer relapse after going off their medications as their brains worked to re-establish equilibrium. With even the intended function of anti-depressants in question, Andrews says it is important to look critically at their continuing use. "It could change the way we think about such major pharmaceutical drugs," he says. "You've got a minimal benefit, a laundry list of negative effects -- some small, some rare and some not so rare. The issue is: does the list of negative effects outweigh the minimal benefit?"
Madeleine McCann as she might look aged 9 Photo: Teri Blythe
Detectives released a new “age progression” image of the toddler, which they said showed what she would look like today at the age of nine.
On Wednesday, Britain’s biggest police force said that as a result of evidence uncovered during a review “they now believe there is a possibility Madeleine is still alive”.
Officers have so far identified nearly 200 new items for investigation within historic material and are also “developing what they believe to be genuinely new material”.
Scotland Yard urged Portuguese authorities to reopen the search for her amid the new "investigative opportunities".
Police said the image, created ahead of what would have been her ninth birthday on May 12, had been created in “close collaboration with the family”.
The mosquito can carry dengue and chikungunya viruses
A mosquito that spreads tropical diseases including dengue fever may be poised to invade the UK because of climate change.
The Asian tiger mosquito has already been reported in France and Belgium and could be migrating north as winters become warmer and wetter.
Scientists have urged "wide surveillance" for the biting insect across countries of central and northern Europe, including the UK.
The mosquito can carry dengue and chikungunya viruses, both of which cause high fevers. The infections usually occur in tropical regions of Africa, Asia and South America.
Scientists led by Dr Samantha Martin, from the University of Liverpool, used climate models to predict how changing conditions might affect Asian tiger mosquito distribution.
They wrote in the Journal of the Royal Society Interface: "Mosquito climate suitability has significantly increased over the southern UK, northern France, the Benelux, parts of Germany, Italy, Sicily and the Balkan countries."
The research shows that parts of the UK could become hot-spots of Asian tiger mosquito activity between 2030 and 2050.
The mosquito has been introduced into Europe from Asia via goods shipments, mainly used tyres and bamboo.
Climate change is now shifting conditions suitable for the insect from southern Europe to central north-western areas.
The mosquito could survive in water butts and vases, and may find winter protection in greenhouses, said the researchers.
Eight American soldiers died of overdoses involving heroin, morphine or other opiates during deployments in Afghanistan in 2010 and 2011, according to U.S. Army investigative reports. The overdoses were revealed in documents detailing how the Army investigated a total of 56 soldiers, including the eight who fell victim to overdoses, on suspicion of possessing, using or distributing heroin and other opiates. At the same time, heroin use apparently is on the rise in the Army overall, as military statistics show that the number of soldiers testing positive for heroin has grown from 10 instances in fiscal year 2002 to 116 in fiscal year 2010. Army officials didn't respond to repeated requests for comment on Saturday. But records from the service's Criminal Investigation Command, obtained by the conservative legal group Judicial Watch, provided glimpses into how soldiers bought drugs from Afghan juveniles, an Afghan interpreter and in one case, an employee of a Defense Department contractor, who was eventually fired. The drug use is occurring in a country that is estimated to supply more than 90% of the world's opium, and the Taliban insurgency is believed to be stockpiling the drug to finance their activities, according to a 2009 U.N. study. While the records show some soldiers using heroin, much of the opiate abuse by U.S. soldiers in Afghanistan involves prescription drugs such Percocet, the Army documents show. Judicial Watch obtained the documents under the Freedom of Information of Act and provided them to CNN. Spokesman Col. Gary Kolb of the International Security Assistance Force, the NATO-led command in Afghanistan, verified the documents to CNN on Saturday. One fatal overdose occurred in June 2010 at Forward Operating Base Blessing, after a soldier asked another soldier to buy black tar opium from a local Afghan outside the base's entry control point. The first soldier died after consuming the opium like chewing tobacco and smoking pieces of it in a cigarette, the documents show. The reports even show soldier lingo for the drug -- calling it "Afghani dip" in one case where three soldiers were accused of using the opiate, the Army investigative reports show. The United States has 89,000 troops in Afghanistan. The U.S. death toll since the September 11, 2001, attacks that triggered the war has risen to more than 1,850, including 82 this year, according to the U.S. Department of Defense and U.S. Central Command. Tom Fitton, president of Judicial Watch, said his group was interested in soldiers' drug use partly because the risk was present during the Vietnam War. "You never want to see news of soldiers dying of drug use in Afghanistan," Fitton said. "Our concern is, will the military treat this as the problem that it is, and are the families of the soldiers aware of the added risk in this drug-infested country? "There is a dotted line between the uses. Prescription abuse can easily veer into heroin drug use," Fitton added. "Afghanistan is the capital of this opiate production and the temptation is great there and the opportunity for drug use all the more." The group is concerned that "there hasn't been enough public discussion, and we would encourage the leadership to discuss or talk about this issue more openly," Fitton said. In one case, a soldier bought heroin and the anti-anxiety drug Xanax from five "local national juveniles at multiple locations on Camp Phoenix, Afghanistan, and consumed them," one report states. Soldiers also distributed heroin, Percocet and other drugs among themselves, according to the reports. Another soldier fatally overdosed in December 2010 after taking several drugs, including morphine and codeine, though the drugs were not prescribed for him, the Army documents show. One female soldier broke into the Brigade Medical Supply Office at Forward Operating Base Shank and stole expired prescription narcotics including morphine, Percocet, Valium, fentanyl and lorazepam, the documents show. The investigative reports show soldiers using other drugs, including steroids and marijuana, and even hashish that was sold to U.S. servicemen by the Afghan National Army and Afghan National Police personnel, the reports state.
Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains.
Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant. How could one substance do all that?
Meet the cannabinoid receptor
In the 1980s and 90s, researchers identified cannabinoid receptors, long, ropy proteins that weave themselves into the surfaces of our cells and process THC. They also process other chemicals, many of them naturally occurring in our bodies. Once we'd discovered these receptors, we knew exactly where THC was being processed in our bodies and brains, as well as what physical systems it was affecting. Scattered throughout the body, cannabinoid receptors come in two varieties, called CB1 and CB2 - most of your CB1 receptors are in your brain, and are responsible for that "high" feeling when you smoke pot. CB2 receptors, often associated with the immune system, are found all over the body. THC interacts with both, which is why the drug gives you the giggles and also (when interacting with the immune system) reduces swelling and pain.
Cannabinoid receptors evolved in sea squirts about 500 million years ago; humans and many other creatures inherited ours from a distant ancestor we share with these simple sea creatures. THC binds to receptors in animals as well as humans, with similar effects.
Tasty, tasty, tasty
Cannabis notoriously makes people hungry - even cancer patients who had lost all desire to eat.One study showed that cancer patients who thought food smelled and tasted awful suddenly regained an ability to appreciate food odors after ingesting a THC compound. There are CB1 receptors in your hypothalamus, a part of your brain known to regulate appetite, and your body's own cannabinoids usually send the "I'm hungry" message to them. But when you ingest THC, you artificially boost the amount of cannabinoids sending that message to your hypothalamus, which is why you get the munchies.
Understanding this process has actually led to a new body of research into safe diet drugs that would block those cannabinoid receptors. That way, your hypothalamus wouldn't receive signals from your body telling it to eat, and would reduce hunger cravings in dieters.
What you're forgetting
What's happening in your brain when smoking pot makes you forget what you're saying in the middle of saying it? According to the book Marijuana and Medicine (National Academies Press):
One of the primary effects of marijuana in humans is disruption of short-term memory. That is consistent with the abundance of CB1 receptors in the hippocampus, the brain region most closely associated with memory. The effects of THC resemble a temporary hippocampal lesion.
That's right - smoking a joint creates the effect of temporary brain damage.
What happens is that THC shuts down a lot of the normal neuroprocessing that goes on in your hippocampus, slowing down the memory process. So memories while stoned are often jumpy, as if parts are missing. That's because parts literally are missing: Basically you are saving a lot less information to your memory. It's not that you've quickly forgotten what's happened. You never remembered it at all.
A bit of the old timey wimey
Cannabis also distorts your sense of time. THC affects your brain's dopamine system, creating a stimulant effect. People who are stoned often report feeling excited, anxious, or energetic as a result. Like other stimulants, this affects people's sense of time. Things seem to pass quickly because the brain's clock is sped up. At the same time, as we discussed earlier (if you can remember), the drug slows down your ability to remember things. That's because it interferes with the brain's acetylcholine system, which is part of what helps you store those memories in your hippocampus. You can see that system's pathway through the brain in red in the illustration at left.
In an article io9 published last year about the neuroscience of time, we noted:
The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.
It's almost as if time is speeding up and slowing down at the same time.
Addiction and medicine
Some experts call cannabis a public health menace that's addictive and destroys lives by robbing people of ambition. Other experts call it a cure for everything from insomnia to glaucoma, and advocate its use as a medicine. The former want it to be illegal; the latter want it prescribed by doctors. Still other groups think it should be treated like other intoxicants such as alcohol and coffee - bad if you become dependent on it, but useful and just plain fun in other situations.
What's the truth? Scientists have proven that cannabis does have medical usefulness, and the more we learn the more intriguing these discoveries become. Since the early 1980s, medical researchers have published about how cannabis relieves pressure in the eye, thus easing the symptoms of glaucoma, a disease that causes blindness. THC is also "neuroprotective," meaning in essence that it prevents brain damage. Some studies have suggested that cannabis could mitigate the effects of Alzheimer's for this reason.
At the same time, we know that THC interferes with memory, and it's still uncertain what kinds of long-term effects the drug could have on memory functioning. No one has been able to prove definitively that it does or does not erode memory strength over time. Obviously, smoking it could cause lung damage. And, like the legal intoxicant alcohol, cannabis can become addictive.
Should cannabis be illegal, while alcohol flows? Unfortunately that's not the kind of question that science can answer. Let's leave the moral questions to courts, policymakers and shamans. I'll be off to the side, smoking a joint, thinking about my acetylcholine system and the many uses of the hippocampus.
U.S. Food and Drug Administration issued new safety information about these cholesterol-lowering drugs that are prescribed to millions of Americans to lower the risk of heart disease. If you're among them, you should understand what the FDA's new guidance means for your health. "Before anyone gets too concerned, you should know that statins are so widely used because they have a long track record of safety and effectiveness," says Dr. Mark Taber, a cardiologist with SSM Heart Institute at St. Joseph Health Center. "All in all, statins have a very high benefit to risk ratio. The widespread use of the drugs, when indicated, probably accounts to a significant degree for the improvement in life expectancy in this country." The FDA called attention to the threat of liver damage as a rare side effect of statins and advised that regular liver enzyme testing is no longer considered useful in predicting or preventing liver injury. "Actually, in general they liberalized the follow up needed for liver function tests on patients taking statins, due to the very low incidence of true liver issues," Taber says. The main warnings related to a slightly higher incidence of developing diabetes while on statins, and a poorly substantiated claim that statins could result in cognitive impairment. Taber points out that cognitive problems, such as confusion or memory problems, were not documented in clinical studies, only by patient reports to the FDA website. "By stating these concerns, the FDA is raising awareness about the potential side effects of statins, but cardiologists already know that there are inherent risks, and we monitor patients appropriately to help ensure that side effects do not occur or are dealt with quickly," Taber notes. "If there is any evidence of a side effect that could be problematic, we can change the medication. But the fact remains that it's important to decrease risk of heart disease, and for many people statins are needed when diet and exercise alone don't result in acceptable cholesterol levels." Whenever a new prescription medication is started, you should look over the package insert to learn about potential side effects. Signs of liver damage, for instance, include fatigue, loss of appetite, right upper abdominal pain, dark urine and jaundice. Any of these symptoms should be reported to your doctor for evaluation. It is important to remember that you should not stop taking a medication without consulting your doctor first. Discontinuing use of a prescribed drug can be far more dangerous than the side effect you're worried about. "All the side effects listed by the FDA are rare, and the risk of heart attack is far more concerning," Taber says. "Some patients may need extra monitoring or may need to try more than one statin before we find the optimal choice, but in general statins are very well tolerated and don't cause problems for the people who take them." The advice above is universal when it comes to your health. Concerns should be discussed with your doctor, and decisions should always be made as part of a team approach to creating a healthy life.
John Holliday had been on a higher 40mg dose of cholesterol pills for only a few weeks when he started to lose his concentration. ‘I’d be watching TV and suddenly find myself unable to follow the plot of a drama,’ says John, 52, a telecoms project manager who lives in Southend-on-Sea, Essex, with his wife Jill, 51, and their two children Adam, 20, and Emma, 16. ‘I’d have to read the same page of a book over and over because I couldn’t take any information in. ‘I’d always been known for my amazing memory — I was great on trivia and had total recall of events that happened 20 years ago, but suddenly I couldn’t remember things and my brain felt fuzzy.’ Just like up to seven million other people in Britain, John had been prescribed a statin to lower his blood cholesterol levels. The drugs are credited by the British Heart Foundation as contributing towards the dramatic 50 per cent fall in deaths from heart attacks in the past ten years. But while there is consensus that statins are lifesavers for people who have previously had a heart attack, concern is growing over their debilitating side-effects. They include muscle weakness, depression, sleep disturbance, sexual dysfunction, muscle pain and damage, gastro-intestinal problems, headaches, joint pains and nausea. Now, official bodies here and in the U.S. have ordered that the drugs must carry warnings for cognitive problems, too. Worryingly, it’s claimed GPs are failing to warn patients of the effect statins can have on the mind — meaning they may mistake them for signs of ageing or Alzheimer’s. ‘When I went back to my doctor after six weeks for a blood test, I told him how dreadful I was feeling,’ says John. ‘But he just said all drugs had side-effects and didn’t mention reducing the dose.’ It's claimed GPs are failing to warn patients of the effect statins can have on the mind - meaning they may mistake them for signs of ageing or Alzheimer's Things came to a head when a friend showed John an electrical circuit he’d built for his car. ‘I’d worked with circuits since I was 16 but it made no sense,’ he says. So John insisted on seeing his doctor again and repeated his concerns about his rapidly declining memory. This time the GP told him he could start on another type of statin when he felt well enough, and so John stopped taking the drugs immediately. ‘It took a few months, but gradually my memory returned and I’ve got my concentration back. I can’t say for sure statins caused these problems, but it seems like too much of a coincidence.’ Earlier this year, the Food and Drug Administration (FDA) in the U.S. ordered statins must carry warnings that some users have reported cognitive problems including memory loss, forgetfulness and confusion. This followed a decision by the UK’s Medicines Healthcare Regulatory Agency (MHRA) to add memory problems to the list of possible statin side-effects in late 2009. The FDA said reports about the symptoms were from across all statin products and age groups. Those affected reported feeling fuzzy or unfocused in their thought process — though these were found to be rare and reversible. The FDA also warned, following U.S. research, that patients on statins had a small excess risk of developing Type 2 diabetes — but stressed that the benefits of taking a statin still outweigh this. The MHRA had 2,675 reports for adverse drug reactions connected with statins between 2007 and 2011. Officially, side-effects are rare —affecting only 1 per cent of people on the pills — but some doctors say they are under-reported. Dr Malcolm Kendrick, a GP and author of The Great Cholesterol Con, says he frequently sees patients suffering from mental confusion in his job in hospital intermediary care for the elderly. ‘Many of the patients I see will have been admitted to hospital after a fall or similar crisis,’ he says. ‘If they appear confused I’ll often advise taking them off statins to see if it has any effect — in my experience, about 10 to 15 per cent of people who appeared to have memory problems experienced an improvement in their memory symptoms after being taken off the drug. ‘I had one dramatic case where a lady was admitted to hospital on 40mg a day of simvastatin with such poor memory function her family asked me about power of attorney. 'I suggested taking her off statins and within a week her memory had returned to normal. She went home a fit and independent 83-year-old.’ Dr Kendrick says cholesterol is the main constituent of synapses (structures that allow signals to pass between brain cells and to create new memories) and is essential for brain function. ‘It is still not proven that statins have a significant effect on mortality — it has been calculated that a man who has had a heart attack who took a statin for five years would extend his life by only 14 days. 'Too many statins are being given to people at low risk. ‘Even in the highest risk group you need to treat 200 people a year with statins to delay just one death. 'One day the harm these drugs are doing is going to be obvious — the benefits are being over-hyped and the risks swept under the carpet.’ While Dr Kendrick’s controversial view is in the minority, one large review of 14 studies by the London School of Hygiene and Tropical Medicine, published by the highly respected Cochrane Library last year, concluded there was ‘little evidence’ cholesterol-lowering drugs protect people who are not at risk of heart disease. This review has been criticised by other doctors who say side-effects are rare and that there are still benefits even for people at lower risk who do not have established heart disease. These defenders of statins include Professor Colin Baigent of the Clinical Trial Service at Oxford University, who published research in 2010 showing statins reduced deaths from all causes by 10 per cent over five years. ‘There is relatively little evidence of cognitive impairment — what evidence there is all comes from observational studies. ‘People read about side-effects and then put two and two together and blame the statins for their muscle pain or other health problems — it’s just not reliable evidence. ‘If you look at the best-quality randomised controlled trial where patients don’t know if they are taking a statin or placebo, there is no evidence of memory problems. 'Even the FDA says the risks of cognitive problems are very small and go away when statins are discontinued. ‘We’re in danger of forgetting just how effective these drugs are.’ Dr Dermot Neely of the charity Heart UK, and lead consultant at the Lipid and Metabolic Clinic at the Royal Victoria Infirmary in Newcastle, agrees side-effects with statins are rare. ‘I’ve been dealing with patients on statins since 1987 and I can count on the fingers of one hand the number whose memory symptoms turned out to be caused by statins.’ However, he said he often saw patients who had not been told about side-effects. ‘It’s important GPs are clear about the drugs statins can interact with, such as certain antibiotics, as this can get overlooked. ‘If a patient notices an adverse effect after starting statins, they should discuss this with their GP —but not stop their drugs suddenly because this can be dangerous.’ Sonya Porter, 73, decided to stop taking statins after her memory problems became so bad that she walked away from a cashpoint leaving her money behind. ‘I was permanently fuzzy-headed and just couldn’t seem to concentrate,’ says Sonya, a retired PA from Woking, Surrey. Then I started to get scared I might have Alzheimer’s. After reading about memory problems associated with statins, I thought it was at least a possibility. I decided to come off the pills to see if it made any difference. ‘I didn’t ask my GP, I just did it — I’d rather die of a heart attack than Alzheimer’s disease. Within a month I felt normal again and didn’t have any problems with memory. ‘I’m terrified that I could have been misdiagnosed with Alzheimer’s.’ John Holliday is also reluctant to go back on statins. ‘I wouldn’t rule it out completely — my latest test showed my cholesterol levels have gone up,’ he says. ‘But on balance, I’d rather take my chances with heart disease than feel as confused as that again. It’s all very well living slightly longer — but it’s about quality of life, too.’
Between 2004 and 2007 there were 282 cocaine-related deaths
In the same period there were 376,000 users per year aged 25 or less
And there were 133,000 over 35s using every year during that time
Men are more than twice as likely to die from cocaine than females
Almost one in 10 Britons aged 15-64 have taken cocaine (and one in seven aged 15-34) - the highest in Europe
Spain next, with 8.3 per cent and Ireland fourth with 8.2 per cent
Usage between 15-34 increased by 50 per cent since 2003
Cannabis still more widely used than cocaine: 75.5million Europeans have smoked (one in four)
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Kilby built and raced cars with the company he owned, Ajec Racing
Police seized 6.5kg of drugs during the operation
A bit of the old timey wimey
